药物毒理学实验课程在临床药学专业人才培养中具有重要地位，但传统教学模式存在诸多不足，亟需改革创新。本文基于海南医科大学五年制临床药学专业的教学实践，从教学内容、教学模式、教学评价等方面入手，对药物毒理学实验课程进行系统的改革探索。主要改革措施包括：整体化设计实验教学内容，突出专业特色；整合线上线下多种教学资源，创新教学模式和方法；建立形成性评价与终结性评价相结合的多元评价体系；将课程思政元素融入教学全过程，强化学生职业素养和责任担当。通过实验改革，学生的实验技能、综合素质和创新能力得到明显提升，教学满意度大幅提高。

The experimental course of pharmacological toxicology plays a vital role in training clinical pharmacy professionals. However, the traditional teaching model has many deficiencies and urgently needs reform and innovation. Based on the teaching practice of the five-year clinical pharmacy major in our university, this paper systematically explores the innovation of the pharmacological toxicology experimental course from aspects such as teaching content, teaching mode and teaching evaluation. The main reform measures include optimizing the experimental teaching content in an integrated manner to highlight professional characteristics; integrating diversified teaching resources both online and offline, and innovating teaching models and methods; establishing a multi-dimensional evaluation system combining formative and summative assessments; and incorporating ideological and political elements into the entire teaching process to strengthen students' professional ethics and sense of responsibility. The innovation practice has achieved remarkable results, with students' experimental skills, comprehensive qualities, and innovative abilities significantly improved and teaching satisfaction greatly enhanced.