抑郁症的药物治疗新进展

张咪雪, 刘莎

PDF(609 KB)
PDF(609 KB)
重庆医科大学学报 ›› 2024, Vol. 49 ›› Issue (05) : 631-637. DOI: 10.13406/j.cnki.cyxb.003506
精神疾病及功能性神经疾病的治疗

抑郁症的药物治疗新进展

作者信息 +

Recent advances in pharmacotherapy for depression

Author information +
History +

摘要

抑郁症(major depression disorder,MDD)是一种常见的精神障碍,严重困扰患者并影响其生活质量,并对社会造成沉重的负担。药物治疗作为抑郁症的主要治疗手段,在抑郁症治疗中发挥着重要作用,随着对抑郁症研究的深入,抗抑郁药物的类型与治疗理念也在不断发展。现基于国内外相关文献及研究资料,对抑郁症药物治疗的进展进行论述。

Abstract

Major depression disorder(MDD) is a common mental disorder that significantly impacts the quality of life of patients and imposes a heavy burden on society. Pharmacotherapy is the main treatment method for MDD and plays a crucial role in the management of MDD. With the in-depth studies on MDD,the types of antidepressive agents and treatment concepts have been developed continuously. This article reviews the advances in pharmacotherapy for MDD based on related articles and research data in China and globally.

关键词

抑郁症 / 药物治疗 / 抗抑郁药物

Key words

major depression disorder / pharmacotherapy / antidepressive agent

中图分类号

R74

引用本文

导出引用
张咪雪 , 刘莎. 抑郁症的药物治疗新进展. 重庆医科大学学报. 2024, 49(05): 631-637 https://doi.org/10.13406/j.cnki.cyxb.003506
Zhang Mixue, Liu Sha. Recent advances in pharmacotherapy for depression[J]. Journal of Chongqing Medical University. 2024, 49(05): 631-637 https://doi.org/10.13406/j.cnki.cyxb.003506

参考文献

1
中华医学会,中华医学会杂志社,中华医学会全科医学分会,等. 抑郁症基层诊疗指南(实践版·2021)[J]. 中华全科医师杂志202120(12):1261-1268.
Chinese Medical Association,Chinese Medical Journals Publishing House,Chinese Society of General Practice,et al. Guideline for primary care of major depressive disorder:practice version(2021)[J]. Chin J Gen Pract202120(12):1261-1268.
2
WHO. Depression and other common mental disorders global health estimates[R]. World Health Organization,2017
3
Yang GH Wang Y Zeng YX,et al. Rapid health transition in China,1990-2010:findings from the Global Burden of Disease Study 2010[J]. Lancet2013381(9882):1987-2015.
4
Huang YQ Wang Y Wang H,et al. Prevalence of mental disorders in China:a cross-sectional epidemiological study[J]. Lancet Psychiatry20196(3):211-224.
5
Lu J Xu XF Huang YQ,et al. Prevalence of depressive disorders and treatment in China:a cross-sectional epidemiological study[J]. Lancet Psychiatry20218(11):981-990.
6
司天梅,王 振,李凌江. 抗抑郁药品临床综合评价专家共识[J]. 中国药房202334(13):1547-1554.
Si TM Wang Z Li LJ. Expert consensus on comprehensive clinical evaluation of antidepressant drugs[J]. China Pharm202334(13):1547-1554.
7
李凌江,马 辛. 中国抑郁障碍防治指南[M]. 2版. 北京:中华医学电子音像出版社,2015:56-67.
Li LJ Ma X. Guidelines for prevention and treatment of depressive disorder in China[M]. 2nd ed.Beijing: Chinese Medical Multimedia Press,2015:56-67.
8
Cipriani A Furukawa TA Salanti G,et al. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder:a systematic review and network meta-analysis[J]. Focus201816(4):420-429.
9
Jannini TB Lorenzo GD Bianciardi E,et al. Off-label uses of selective serotonin reuptake inhibitors (SSRIs)[J]. Curr Neuropharmacol202220(4):693-712.
10
Thom RP Alexander JL Baron D,et al. Selective serotonin reuptake inhibitors:how long is long enough?[J]. J Psychiatr Pract202127(5):361-371.
11
Maneeton N Maneeton B Eurviriyanukul K,et al. Efficacy,tolerability,and acceptability of bupropion for major depressive disorder:a meta-analysis of randomized-controlled trials comparison with venlafaxine[J]. Drug Des Devel Ther20137:1053-1062.
12
Konstantakopoulos G Dimitrakopoulos S Michalopoulou PG. The preclinical discovery and development of agomelatine for the treatment of depression[J]. Expert Opin Drug Discov202015(10):1121-1132.
13
Kishi T Ikuta T Sakuma K,et al. Antidepressants for the treatment of adults with major depressive disorder in the maintenance phase:a systematic review and network meta-analysis[J]. Mol Psychiatry202328(1):402-409.
14
Li ZJ Liu SH Wu QX,et al. Effectiveness and safety of vortioxetine for the treatment of major depressive disorder in the real world:a systematic review and meta-analysis[J]. Int J Neuropsychopharmacol202326(6):373-384.
15
Holper L Hengartner MP. Comparative efficacy of placebos in short-term antidepressant trials for major depression:a secondary meta-analysis of placebo-controlled trials[J]. BMC Psychiatry202020(1):437.
16
Vasiliu O. Efficacy,tolerability,and safety of toludesvenlafaxine for the treatment of major depressive disorder-a narrative review[J]. Pharmaceuticals202316(3):411.
17
Zhu HB Wang WY Sha CJ,et al. Pharmacological characterization of toludesvenlafaxine as a triple reuptake inhibitor[J]. Front Pharmacol202112:741794.
18
Mi WF Di XL Wang YM,et al. A phase 3,multicenter,double-blind,randomized,placebo-controlled clinical trial to verify the efficacy and safety of ansofaxine (LY03005) for major depressive disorder[J]. Transl Psychiatry202313(1):163.
19
Mi WF Yang FD Li HF,et al. Efficacy,safety,and tolerability of ansofaxine (LY03005) extended-release tablet for major depressive disorder:a randomized,double-blind,placebo-controlled,dose-finding,phase 2 clinical trial[J]. Int J Neuropsychopharmacol202225(3):252-260.
20
Xiong JQ Lipsitz O Chen-Li D,et al. The acute antisuicidal effects of single-dose intravenous ketamine and intranasal esketamine in individuals with major depression and bipolar disorders:a systematic review and meta-analysis[J]. J Psychiatr Res2021134:57-68.
21
Daly EJ Singh JB Fedgchin M,et al. Efficacy and safety of intranasal esketamine adjunctive to oral antidepressant therapy in treatment-resistant depression:a randomized clinical trial[J]. JAMA Psychiatry201875(2):139-148.
22
Fu DJ Ionescu DF Li X,et al. Esketamine nasal spray for rapid reduction of major depressive disorder symptoms in patients who have active suicidal ideation with intent:double-blind,randomized study (ASPIRE I)[J]. J Clin Psychiatry202081(3):19m13191.
23
Reif A Bitter I Buyze J,et al. Esketamine nasal spray versus quetiapine for treatment-resistant depression[J]. N Engl J Med2023389(14):1298-1309.
24
Ionescu DF Fu DJ Qiu X,et al. Esketamine nasal spray for rapid reduction of depressive symptoms in patients with major depressive disorder who have active suicide ideation with intent:results of a phase 3,double-blind,randomized study(ASPIRE Ⅱ)[J]. Int J Neuropsychopharmacol202124(1):22-31.
25
McCarron RM Shapiro B Rawles J,et al. Depression[J]. Ann Intern Med2021:AITC202105180.
26
Taylor D Paton C Kapur S. Maudsley 精神科处方指南[M]. 12版.司天梅,译.北京:人民卫生出版社,2015:184-196.
Taylor D Paton C Kapur S. The Maudsley prescribing guidelines in psychiatry[M]. 12th ed. Si TM,translation. Beijing:People's Medical Publishing House,2015:184-196.
27
Chaki S Watanabe M. Antidepressants in the post-ketamine Era:Pharmacological approaches targeting the glutamatergic system[J]. Neuropharmacology2023223:109348.
28
Tabuteau H Jones A Anderson A,et al. Effect of AXS-05 (dextromethorphan-bupropion) in major depressive disorder:a randomized double-blind controlled trial[J]. Am J Psychiatry2022179(7):490-499.
29
Keam SJ. Dextromethorphan/bupropion:first approval[J]. CNS Drugs202236(11):1229-1238.
30
Iosifescu DV Jones A O'Gorman C,et al. Efficacy and safety of AXS-05 (dextromethorphan-bupropion) in patients with major depressive disorder:a phase 3 randomized clinical trial (GEMINI)[J]. J Clin Psychiatry202283(4):21m14345.
31
Heo YA. Zuranolone:first approval[J]. Drugs202383(16):1559-1567.
32
Clayton AH Lasser R Parikh SV,et al. Zuranolone for the treatment of adults with major depressive disorder:a randomized,placebo-controlled phase 3 trial[J]. Am J Psychiatry2023180(9):676-684.
33
Deligiannidis KM Meltzer-Brody S Maximos B,et al. Zuranolone for the treatment of postpartum depression[J]. Am J Psychiatry2023180(9):668-675.
34
Cutler AJ Mattingly GW Kornstein SG,et al. Long-term safety and efficacy of initial and repeat treatment courses with zuranolone in adult patients with major depressive disorder:interim results from the open-label,phase 3 SHORELINE study[J]. J Clin Psychiatry202385(1):23m14845.
35
Li ZJ Wu QX Peng P,et al. Efficacy and safety of zuranolone for the treatment of depression:a systematic review and meta-analysis[J]. Psychiatry Res2024331:115640.
36
Lin YW Tu YK Hung KC,et al. Efficacy and safety of zuranolone in major depressive disorder:a meta-analysis of factor effect and dose-response analyses[J]. E Clinical Medicine202366:102308.
37
胡昌清,朱雪泉,丰雷,等. 中国抑郁障碍防治指南(第二版)解读:药物治疗原则[J]. 中华精神科杂志201750(3):172-174.
Hu CQ Zhu XQ Feng L,et al. Interpretation of the guideline for prevention and treatment of depression in China(Second Edition):drug therapy principles[J]. Chinese Journal of Psychiatry201750(3):172-174.
38
Cipriani A Zhou XY Del Giovane C,et al. Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents:a network meta-analysis[J]. Lancet2016388(10047):881-890.
39
Hetrick SE McKenzie JE Bailey AP,et al. New generation antidepressants for depression in children and adolescents:a network meta-analysis[J]. Cochrane Database Syst Rev20215(5):CD013674.
40
Hopkins K Crosland P Elliott N,et al. Diagnosis and management of depression in children and young people: summary of updated NICE guidance[J]. Br J Sports Med201650(3):184-186.
41
Murphy SE Capitão LP Giles SLC,et al. The knowns and unknowns of SSRI treatment in young people with depression and anxiety:efficacy,predictors,and mechanisms of action[J]. Lancet Psychiatry20218(9):824-835.
42
中华医学会精神医学分会老年精神医学组. 老年期抑郁障碍诊疗专家共识[J]. 中华精神科杂志201750(5):329-334.
Geriatric Psychiatry Group of Chinese Society of Psychiatry. Expert consensus on diagnosis and treatment of senile depression[J]. Chin J Psychiatry201750(5):329-334.
43
Lenze EJ Mulsant BH Roose SP,et al. Antidepressant augmentation versus switch in treatment-resistant geriatric depression[J]. N Engl J Med2023388(12):1067-1079.
44
Eleftheriou G Zandonella Callegher R Butera R,et al. Consensus panel recommendations for the pharmacological management of pregnant women with depressive disorders[J]. Int J Environ Res Public Health202320(16):6565.
45
潘 攀,傅潇雅,胡少华,等. 常见慢性躯体疾病共病抑郁障碍的规范化阶梯治疗选择指导建议[J]. 临床精神医学杂志202232(6):497-501.
Pan P Fu XY Hu SH,et al. Guidelines and recommendations of stepwise treatment options for common chronic somatic diseases co- morbidity with major depressive disorder[J]. J Clin Psychiatry202232(6):497-501.
46
Ziegelstein RC Meuchel J Kim TJ,et al. Selective serotonin reuptake inhibitor use by patients with acute coronary syndromes[J]. Am J Med2007120(6):525-530.
47
Sforzini L Pariante CM Palacios JE,et al. Inflammation associated with coronary heart disease predicts onset of depression in a three-year prospective follow-up:a preliminary study[J]. Brain Behav Immun201981:659-664.
48
Castilla-Guerra L Fernandez Moreno MDC Esparrago-Llorca G,et al. Pharmacological management of post-stroke depression[J]. Expert Rev Neurother202020(2):157-166.
49
王少石,周新雨,朱春燕. 卒中后抑郁临床实践的中国专家共识[J]. 中国卒中杂志201611(8):685-693.
Wang SS Zhou XY Zhu CY. China expert consensus on clinical practice of post-stroke depression[J]. Chin J Stroke201611(8):685-693.
50
Vita G Compri B Matcham F,et al. Antidepressants for the treatment of depression in people with cancer[J]. Cochrane Database Syst Rev20233(3):CD011006.
51
Azari L Hemati H Tavasolian R,et al. The efficacy and safety of ketamine for depression in patients with cancer:a systematic review[J]. Int J Clin Health Psychol202424(1):100428.

基金

国家重点研发计划资助项目(2023YFC2506201)
国家自然科学基金面上资助项目(82271546)
山西省科技创新人才团队资助项目(202304051001049)
山西省基础研究面上资助项目(202203021211018)

评论

PDF(609 KB)

Accesses

Citation

Detail

段落导航
相关文章

/