常见3种神经痛的机制与治疗进展

许鸿嘉, 张烨, 张庆硕, 韩晓旭, 许顺良

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重庆医科大学学报 ›› 2024, Vol. 49 ›› Issue (05) : 583-587. DOI: 10.13406/j.cnki.cyxb.003493
神经系统发作性疾病与癫痫的治疗

常见3种神经痛的机制与治疗进展

作者信息 +

Advances in the mechanisms and treatment of three common types of neuralgia

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摘要

神经痛指由神经系统疾病或损伤而导致的剧烈疼痛。神经痛的特点为具有强烈的痛苦感和慢性发作,给患者造成极大的身心折磨,降低患者生活质量。因此,探究神经痛的机制及规范诊疗方案十分重要。目前神经痛的治疗方案包括药物治疗、介入治疗等多种方式。本文对目前神经痛新机制及新治疗方案进行综述,以加深临床医师对神经痛新进展的认识。

Abstract

Neuralgia refers to severe pain caused by nervous system diseases or injuries and is characterized by a strong sense of pain and chronic attacks,thereby causing great physical and mental torture to patients and reducing their quality of life. Therefore,it is of great importance to explore the mechanism of neuralgia and standardized diagnosis and treatment regimens. Currently,the treatment options for neuralgia include medication and interventional therapy. This article summarizes the new mechanisms of neuralgia and the new treatment options at present,so as to deepen the understanding of the new advances in neuralgia among clinicians.

关键词

神经痛 / 发病机制 / 治疗 / 进展

Key words

neuralgia / pathogenesis / treatment / advances

中图分类号

R745

引用本文

导出引用
许鸿嘉 , 张烨 , 张庆硕 , . 常见3种神经痛的机制与治疗进展. 重庆医科大学学报. 2024, 49(05): 583-587 https://doi.org/10.13406/j.cnki.cyxb.003493
Xu Hongjia, Zhang Ye, Zhang Qingshuo, et al. Advances in the mechanisms and treatment of three common types of neuralgia[J]. Journal of Chongqing Medical University. 2024, 49(05): 583-587 https://doi.org/10.13406/j.cnki.cyxb.003493

参考文献

1
Finnerup NB Kuner R Jensen TS. Neuropathic pain:from mechanisms to treatment[J]. Physiol Rev2021101(1):259-301.
2
Finnerup NB Attal N Haroutounian S,et al. Pharmacotherapy for neuropathic pain in adults:a systematic review and meta-analysis[J]. Lancet Neurol201514(2):162-173.
3
Ericson H Abu Hamdeh S Freyhult E,et al. Cerebrospinal fluid biomarkers of inflammation in trigeminal neuralgia patients operated with microvascular decompression[J]. Pain2019160(11):2603-2611.
4
Ito E Seki Y Saito K,et al. Increased cerebrospinal fluid S100B protein levels in patients with trigeminal neuralgia and hemifacial spasm[J]. Acta Neurochir2023165(4):959-965.
5
Li M Yan JH Wen H,et al. Cortical thickness,gyrification and sulcal depth in trigeminal neuralgia[J]. Sci Rep202111(1):16322.
6
Li S Liao CL Qian MQ,et al. Narrow ovale foramina may be involved in the development of primary trigeminal neuralgia[J]. Front Neurol202213:1013216.
7
Gambeta E Chichorro JG Zamponi GW. Trigeminal neuralgia:an overview from pathophysiology to pharmacological treatments[J]. Mol Pain202016:1744806920901890.
8
Liu MX Zhong J Xia L,et al. The expression of voltage-gated sodium channels in trigeminal nerve following chronic constriction injury in rats[J]. Int J Neurosci2019129(10):955-962.
9
Gualdani R Gailly P Yuan JH,et al. A TRPM7 mutation linked to familial trigeminal neuralgia:Omega current and hyperexcitability of trigeminal ganglion neurons[J]. Proc Natl Acad Sci USA2022119(38):e2119630119.
10
Muñoz-Vendrell A Teixidor S Sala-Padró J,et al. Intravenous lacosamide and phenytoin for the treatment of acute exacerbations of trigeminal neuralgia:a retrospective analysis of 144 cases[J]. Cephalalgia202242(10):1031-1038.
11
Zhou XJ Shen Y Zhao CM,et al. Lidocaine aerosol sprayed on oral and/or nasal mucosa for the rescue of acute trigeminal neuralgia exacerbations:a retrospective study[J]. Cephalalgia202343(5):3331024231168086.
12
Bendtsen L Zakrzewska JM Abbott J,et al. European Academy of Neurology guideline on trigeminal neuralgia[J]. Eur J Neurol201926(6):831-849.
13
Bendtsen L Zakrzewska JM Heinskou TB,et al. Advances in diagnosis,classification,pathophysiology,and management of trigeminal neuralgia[J]. Lancet Neurol202019(9):784-796.
14
Tereshko Y Valente M Belgrado E,et al. The therapeutic effect of botulinum toxin type A on trigeminal neuralgia:are there any differences between type 1 versus type 2 trigeminal neuralgia?[J]. Toxins202315(11):654.
15
Zakrzewska JM Palmer J Morisset V,et al. Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia:a double-blind,placebo-controlled,randomised withdrawal phase 2a trial[J]. Lancet Neurol201716(4):291-300.
16
Rana MH Khan AAG Khalid I,et al. Therapeutic approach for trigeminal neuralgia:a systematic review[J]. Biomedicines202311(10):2606.
17
Gonzalez-Quarante LH Ruiz-Juretschke F Agarwal V,et al. Microvascular decompression for trigeminal neuralgia using a novel fenestrated clip and tentorial flap technique[J]. World Neurosurg2017106:775-784.
18
Yan CY Zhang QX Liu C,et al. Efficacy and safety of radiofrequency in the treatment of trigeminal neuralgia:a systematic review and meta-analysis[J]. Acta Neurol Belg2022122(4):1019-1030.
19
Xu RS Materi J Raj D,et al. Internal neurolysis versus intraoperative glycerin rhizotomy for trigeminal neuralgia[J]. J Neurosurg2023138(1):270-275.
20
Spatz AL Zakrzewska JM Kay EJ. Decision analysis of medical and surgical treatments for trigeminal neuralgia:how patient evaluations of benefits and risks affect the utility of treatment decisions[J]. Pain2007131(3):302-310.
21
Zhao QY He G Zhang ZY,et al. Efficacy and safety of acupuncture for trigeminal neuralgia:a protocol for systematic review and meta-analysis[J]. Medicine202099(40):e22589.
22
Ichida MC Zemuner M Hosomi J,et al. Acupuncture treatment for idiopathic trigeminal neuralgia:a longitudinal case-control double blinded study[J]. Chin J Integr Med201723(11):829-836.
23
Zhi HW Jia YZ Bo HQ,et al. Curcumin alleviates orofacial allodynia and improves cognitive impairment via regulating hippocampal synaptic plasticity in a mouse model of trigeminal neuralgia[J]. Aging202315(16):8458-8470.
24
Kennedy PG Montague P Scott F,et al. Varicella-zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line[J]. PLoS One20138(1):e51570.
25
Chen FX Chen FY Shang ZF,et al. White matter microstructure degenerates in patients with postherpetic neuralgia[J]. Neurosci Lett2017656:152-157.
26
Chen K Wang M Long DJ,et al. Cerebrospinal fluid proteomic profiles in patients with postherpetic neuralgia[J]. J Proteome Res202322(12):3879-3892.
27
Kawashima M Miyachi Y. A 1-year survey of zoster-associated pain after amenamevir treatment[J]. Dermatol Ther202212(5):1239-1252.
28
Kato J Matsui N Kakehi Y,et al. Mirogabalin for the management of postherpetic neuralgia:a randomized,double-blind,placebo-controlled phase 3 study in Asian patients[J]. Pain2019160(5):1175-1185.
29
Gavin PD Tremper L Smith A,et al. Transdermal oxycodone patch for the treatment of postherpetic neuralgia:a randomized,double-blind,controlled trial[J]. Pain Manag20177(4):255-267.
30
Huerta Garcia MM García-Parra B,et al. Investigational drugs for the treatment of postherpetic neuralgia:systematic review of randomized controlled trials[J]. Int J Mol Sci202324(16):12987.
31
Yen FS Wei JC Yip HT,et al. Metformin use and the risks of herpes zoster and postherpetic neuralgia in patients with type 2 diabetes[J]. J Med Virol202395(1):e28278.
32
Lin CS Lin YC Lao HC,et al. Interventional treatments for postherpetic neuralgia:a systematic review[J]. Pain Physician201922(3):209-228.
33
Zhang EM Fei Y Xu LS,et al. Effect of repeated high-voltage long-duration pulsed radiofrequency on herpetic neuralgia[J]. Pain Physician202225(7):E1047-E1055.
34
Sun CL Li XL Li CW,et al. High-voltage,long-duration pulsed radiofrequency to the dorsal root ganglion provides improved pain relief for Herpes zoster neuralgia in the subacute stage[J]. Pain Physician202326(3):E155-E162.
35
Huang SJ Xu YP Pan ZQ,et al. Efficacy and safety of fire needle combined with cupping for acute herpes zoster and postherpetic neuralgia:a protocol for systemic review and meta-analysis[J]. Medicine2022101(50):e32251.
36
Jeon H Lee SJ Kim SA,et al. Oral herbal medicine for treatment of postherpetic neuralgia:a protocol for systematic review and meta-analysis[J]. Medicine2022101(52):e32484.
37
Volokitin M Izadi N Myers R,et al. Osteopathic manipulative treatment of Herpes zoster Ophthalmicus/postherpetic neuralgia[J]. Cureus202113(5):e14906.
38
Rosenberger DC Blechschmidt V Timmerman H,et al. Challenges of neuropathic pain:focus on diabetic neuropathy[J]. J Neural Transm2020127(4):589-624.
39
Wang AH Shi XC Yu RY,et al. The P2X7 receptor is involved in diabetic neuropathic pain hypersensitivity mediated by TRPV1 in the rat dorsal root ganglion[J]. Front Mol Neurosci202114:663649.
40
Song ZH Song XJ Yang CL,et al. Up-regulation of microglial chemokine CXCL12 in anterior cingulate cortex mediates neuropathic pain in diabetic mice[J]. Acta Pharmacol Sin202344(7):1337-1349.
41
Tatikola SP Natarajan V Desai VK,et al. Effect of various exercise protocols on neuropathic pain in individuals with type 2 diabetes with peripheral neuropathy:a systematic review and meta-analysis[J]. Diabetes Metab Syndr202216(9):102603.
42
Baba M Matsui N Kuroha M,et al. Mirogabalin for the treatment of diabetic peripheral neuropathic pain:a randomized,double-blind,placebo-controlled phase Ⅲ study in Asian patients[J]. J Diabetes Investig201910(5):1299-1306.
43
Price R Smith D Franklin G,et al. Oral and topical treatment of painful diabetic polyneuropathy:practice guideline update summary:report of the AAN guideline subcommittee[J]. Neurology202298(1):31-43.
44
Alsaloum M Higerd GP Effraim PR,et al. Status of peripheral sodium channel blockers for non-addictive pain treatment[J]. Nat Rev Neurol202016(12):689-705.
45
Ghoreishi-Haack N Priebe JM Aguado JD,et al. NYX-2925 is a novel N-methyl-D-aspartate receptor modulator that induces rapid and long-lasting analgesia in rat models of neuropathic pain[J]. J Pharmacol Exp Ther2018366(3):485-497.
46
Du ZL Zhang J Han X,et al. Potential novel therapeutic strategies for neuropathic pain[J]. Front Mol Neurosci202316:1138798.
47
James CF. Pharmacotherapy of painful diabetic neuropathy:a clinical update[J]. Sisli Etfal202256(1):1-20.
48
Zuidema X de Galan B Brouwer B,et al. 4. Painful diabetic polyneuropathy[J]. Pain Pract202424(2):308-320.

基金

山东省重点研发计划资助项目(2019GSF108066)
山东省自然科学基金资助项目(ZR2015HM024)

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