帕金森病步态障碍的侵入性神经调控治疗进展

曾志童; 黄鹏; 孙伯民; 李殿友

doi:10.13406/j.cnki.cyxb.003486

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重庆医科大学学报 ›› 2024, Vol. 49 ›› Issue (05) : 548-551. DOI: 10.13406/j.cnki.cyxb.003486

运动障碍性疾病的治疗

帕金森病步态障碍的侵入性神经调控治疗进展

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Advances in invasive neuromodulation therapy for gait disturbance in Parkinson's disease

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摘要

步态障碍是帕金森病（Parkinson's disease，PD）最常见的中轴症状之一，严重损害患者活动能力和生活质量。神经调控是PD步态障碍药物、运动和康复治疗之外的重要疗法，其中侵入性手术是常采用的调控手段。鉴于步态障碍的高发病率和现有疗法的疗效局限性，近年来侵入性神经调控出现了许多针对新靶点和新模式的研究。本文对侵入性神经调控在治疗PD步态障碍方面取得的一些进展进行综述和展望。

Abstract

Gait disturbance is one of the most common axial symptoms in Parkinson's disease（PD），and it severely impairs the mobility and quality of life of patients. Neuromodulation is an important therapy in addition to pharmacotherapy，exercise，and rehabilitation，among which invasive surgery is a commonly used modulation method. Due to the high prevalence rate of gait disturbance in PD and the limitations of existing therapies，studies for new targets and techniques have been conducted for invasive neuromodulation in recent years. This article reviews the advances and prospects of invasive neuromodulation in the treatment of gait disturbance in PD.

关键词

帕金森病 / 步态障碍 / 侵入性神经调控 / 脑深部电刺激

Key words

Parkinson's disease / gait disturbance / invasive neuromodulation / deep brain stimulation

中图分类号

R742.5 / R651

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曾志童 , 黄鹏 , 孙伯民 , 等. 帕金森病步态障碍的侵入性神经调控治疗进展. 重庆医科大学学报. 2024, 49(05): 548-551 https://doi.org/10.13406/j.cnki.cyxb.003486

Zeng Zhitong, Huang Peng, Sun Bomin, et al. Advances in invasive neuromodulation therapy for gait disturbance in Parkinson's disease[J]. Journal of Chongqing Medical University. 2024, 49(05): 548-551 https://doi.org/10.13406/j.cnki.cyxb.003486

参考文献

列表( 原文顺序 | 文献年度倒序 | 文中引用次数倒序 ) 可视化分析

1	Mirelman A， Bonato P， Camicioli R，et al. Gait impairments in Parkinson's disease[J]. Lancet Neurol，2019，18（7）：697-708．本文引用 [1]

2	Giladi N， Horak FB， Hausdorff JM. Classification of gait disturbances：distinguishing between continuous and episodic changes[J]. Mov Disord，2013，28（11）：1469-1473．本文引用 [1]

中华医学会神经病学分会帕金森病及运动障碍学组，中国医师协会神经内科医师分会帕金森病及运动障碍学组. 中国帕金森病治疗指南（第四版）[J]. 中华神经科杂志，2020，53（12）：973-986.

Chinese Society of Parkinson's Disease and Movement Disorders，Parkinson's disease and movement disorder section of neurologist branch of Chinese medical doctor association. Chinese guidelines for the treatment of Parkinson's disease（fourth edition）[J]. Chinese Journal of Neurology，2020，53（12）：973-986.

本文引用 [2]

4	曹学兵，唐北沙，刘振国. 帕金森病冻结步态中西医诊治专家共识（2021）[J]. 卒中与神经疾病，2021，28（5）：599-604． Cao XB， Tang BS， Liu ZG. Consensus of experts in diagnosis and treatment of Parkinson's disease with frozen gait（2021）[J]. Stroke Nerv Dis，2021，28（5）：599-604．本文引用 [1]

5	Tykocki T， Mandat T， Nauman P. Pedunculopontine nucleus deep brain stimulation in Parkinson's disease[J]. Arch Med Sci，2011，7（4）：555-564．本文引用 [2]

6	Bourilhon J， Olivier C， You HN，et al. Pedunculopontine and cuneiform nuclei deep brain stimulation for severe gait and balance disorders in Parkinson's disease：interim results from a randomized double-blind clinical trial[J]. J Parkinsons Dis，2022，12（2）：639-653．本文引用 [1]

7	Bourilhon J， Mullie Y， Olivier C，et al. Stimulation of the pedunculopontine and cuneiform nuclei for freezing of gait and falls in Parkinson disease：cross-over single-blinded study and long-term follow-up[J]. Parkinsonism Relat Disord，2022，96：13-17．本文引用 [1]

8	Weiss D， Walach M， Meisner C，et al. Nigral stimulation for resistant axial motor impairment in Parkinson's disease?A randomized controlled trial[J]. Brain，2013，136（Pt 7）：2098-2108．本文引用 [1]

Valldeoriola

. Simultaneous low-frequency deep brain stimulation of the substantia nigra pars reticulata and high-frequency stimulation of the subthalamic nucleus to treat levodopa unresponsive freezing of gait in Parkinson's disease：a pilot study[J]. Parkinsonism Relat Disord，2019，63：231．

本文引用 [1]

10	Scholten M， Klemt J， Heilbronn M，et al. Effects of subthalamic and nigral stimulation on gait kinematics in Parkinson's disease[J]. Front Neurol，2017，8：543．本文引用 [1]

11	Heilbronn M， Scholten M， Schlenstedt C，et al. Anticipatory postural adjustments are modulated by substantia nigra stimulation in people with Parkinson's disease and freezing of gait[J]. Parkinsonism Relat Disord，2019，66：34-39．本文引用 [1]

12	Cury RG， Pavese N， Aziz TZ，et al. Gaps and roadmap of novel neuromodulation targets for treatment of gait in Parkinson's disease[J]. NPJ Parkinsons Dis，2022，8（1）：8．本文引用 [1]

13	Lizarraga KJ， Luca CC， De Salles A，et al. Asymmetric neuromodulation of motor circuits in Parkinson's disease：the role of subthalamic deep brain stimulation[J]. Surg Neurol Int，2017，8：261．本文引用 [1]

14	Meoni S， Debû B， Pelissier P，et al. Asymmetric STN DBS for FOG in Parkinson's disease：a pilot trial[J]. Parkinsonism Relat Disord，2019，63：94-99．本文引用 [1]

15	Lizárraga KJ， Gnanamanogaran B， Al-Ozzi TM，et al. Lateralized subthalamic stimulation for axial dysfunction in Parkinson's disease：a randomized trial[J]. Mov Disord，2022，37（5）：1079-1087．本文引用 [1]

16	Xie T， Padmanaban M， Bloom L，et al. Effect of low versus high frequency stimulation on freezing of gait and other axial symptoms in Parkinson patients with bilateral STN DBS：a mini-review[J]. Transl Neurodegener，2017，6：13．本文引用 [2]

17	Moreau C， Defebvre L， Destee A，et al. STN-DBS frequency effects on freezing of gait in advanced Parkinson disease[J]. Neurology，2008，71（2）：80-84. 本文引用 [1]

18	Vijiaratnam N， Girges C， Wirth T，et al. Long-term success of low-frequency subthalamic nucleus stimulation for Parkinson's disease depends on tremor severity and symptom duration[J]. Brain Commun，2021，3（3）：fcab165．本文引用 [1]

19	Annic A， Moreau C， Salleron J，et al. Predictive factors for improvement of gait by low-frequency stimulation in Parkinson's disease[J]. J Parkinsons Dis，2014，4（3）：413-420．本文引用 [1]

20	Su DN， Chen HM， Hu WL，et al. Frequency-dependent effects of subthalamic deep brain stimulation on motor symptoms in Parkinson's disease：a meta-analysis of controlled trials[J]. Sci Rep，2018，8（1）：14456．本文引用 [1]

21	Jia FM， Guo Y， Wan S，et al. Variable frequency stimulation of subthalamic nucleus for freezing of gait in Parkinson's disease[J]. Parkinsonism Relat Disord，2015，21（12）：1471-1472．本文引用 [3]

22	Jia FM， Hu W， Zhang JG，et al. Variable frequency stimulation of subthalamic nucleus in Parkinson's disease：rationale and hypothesis[J]. Parkinsonism Relat Disord，2017，39：27-30．本文引用 [1]

23	Jia FM， Wagle Shukla A， Hu W，et al. Deep brain stimulation at variable frequency to improve motor outcomes in Parkinson's disease[J]. Mov Disord Clin Pract，2018，5（5）：538-541．本文引用 [1]

24	Jia FM， Zhang JG， Wang HM，et al. Variable- versus constant-frequency deep-brain stimulation in patients with advanced Parkinson's disease：study protocol for a randomized controlled trial[J]. Trials，2019，20（1）：749．本文引用 [3]

25	Petrucci MN， Neuville RS， Afzal MF，et al. Neural closed-loop deep brain stimulation for freezing of gait[J]. Brain Stimul，2020，13（5）：1320-1322．本文引用 [1]

26	Molina R， Hass CJ， Cernera S，et al. Closed-loop deep brain stimulation to treat medication-refractory freezing of gait in Parkinson's disease[J]. Front Hum Neurosci，2021，15：633655．本文引用 [1]

27	Streumer J， Selvaraj AK， Kurt E，et al. Does spinal cord stimulation improve gait in Parkinson's disease：a comprehensive review[J]. Parkinsonism Relat Disord，2023，109：105331．本文引用 [4]

28	Samotus O， Parrent A， Jog M. Spinal cord stimulation therapy for gait dysfunction in advanced Parkinson's disease patients[J]. Mov Disord，2018，33（5）：783-792．本文引用 [1]

29	Prasad S， Aguirre-Padilla DH， Poon YY，et al. Spinal cord stimulation for very advanced Parkinson's disease：a 1-year prospective trial[J]. Mov Disord，2020，35（6）：1082-1083．本文引用 [1]

30	Zhang CC， Wang LB， Pan YX，et al. Sacral nerve stimulation improves gait in Parkinson's disease[J]. Brain Stimul，2019，12（4）：1075-1076．本文引用 [1]

31	Gilat M， Ginis P， Zoetewei D，et al. A systematic review on exercise and training-based interventions for freezing of gait in Parkinson's disease[J]. NPJ Parkinsons Dis，2021，7（1）：81．本文引用 [1]

32	Nonnekes J， Snijders AH， Nutt JG，et al. Freezing of gait：a practical approach to management[J]. Lancet Neurol，2015，14（7）：768-778．本文引用 [1]

33	Milekovic T， Moraud EM， Macellari N，et al. A spinal cord neuroprosthesis for locomotor deficits due to Parkinson's disease[J]. Nat Med，2023，29（11）：2854-2865．本文引用 [1]

基金

国家自然科学基金面上资助项目(81971294)

上海市科委“科技创新行动计划”资助项目(22Y11903900)

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Received	Published
2024-01-26	2024-05-28
Issue Date
2024-05-28

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