LUO Fuguang, HUANG Jie, WANG Zhiqiang, HUANG Desheng, LI Ming, SI Zaiyong, GUO Zhongbao
Objectives The drug resistance characteristics of Streptococcus agalactiae and Streptococcus iniae from fish to different antibiotics and its correlation with drug efficacy in the practice of production were studied to provide a reference for rational drug use in fish derived Streptococcus infections. Methods Statistical comparison of the reported literature from 2013 to 2022 and the resistance characteristics of 183 strains of fish derived streptococci purified and isolated in the author's laboratory to 13 conventional antibiotics was conducted. Evaluate The scientific guidance of drug sensitivity testing was evaluated based on drug efficacy in the practice of production. Results 141 strains of S. agalactiae had high resistance rates to sulfadiazine, trimethoprim/sulfamethoxazole, sulfamethoxazole, neomycin, and 42 strains of S. iniae had high resistance rates to sulfadiazine and neomycin, with rates of 100%, 100%, 99%, 82%, 100%, and 100%, respectively. 141 strains of S. agalactia and 42 strains of S. iniae had no resistance to penicillin, ampicillin, amoxicillin, doxycycline, enrofloxacin, ciprofloxacin, ofloxacin, lofloxacin and florfenicol, which were similar to the types of drugs with high and low resistance rates reported in literature from 2013 to 2022. Sulfonamide drugs with high resistance rates determined by drug sensitivity testing had an effective rate of over 75% in the treatment of fish derived Streptococcus infections. Conclusions It is indicated that sulfonamides, florfenicol, and other drugs in the susceptibility test of fish Streptococcus are not applicable according to the existing judgment standards, and new judgment standards and dosage instructions for fishing drugs should be established. The results of testing sensitivity in vitro of fish derived Streptococcus to drugs including florfenicol, doxycycline, enrofloxacin, ciprofloxacin, ofloxacin, and levofloxacin is inconsistent with the drug efficacy in the practice of clinics. Therefore, antibiotics should be used cautiously in case of single infection.