Pharmacology, as a core basic course of clinical medicine, pharmacy and other majors in medical colleges and universities, is an important bridge connecting basic medicine, pharmacy and clinical medicine. Students generally report that pharmacology is abstract in content, has numerous knowledge points, is difficult to learn and remember, and is prone to problems such as fear of difficulties in the learning process. Traditional teaching models are difficult to meet students' learning needs. This study is based on the concept of outcome-based education (OBE), focusing on the requirements of medical personnel training under the background of new quality productivity in the new era, through the online and offline organic combination of pharmacology mixed interactive teaching mode, balanced use of a variety of teaching methods, strengthen the effective and close integration of basic medicine and clinical medicine, and help improve the quality of talent training; train students from the absorption of low-level procedural knowledge to the absorption of high-level procedural knowledge and strategic knowledge, and promote students to build a pharmacological knowledge system based on clinical thinking and integrates it into their minds and hearts. This model effectively compensates for the shortcomings of traditional teaching, cultivates students' preliminary clinical thinking and scientific research thinking, significantly improves students' self-learning ability and learning effectiveness, and promotes the improvement of students' comprehensive quality and ability.