Objective To analyze the engagement in blended learning and its influencing factors to provide references for optimizing the blended teaching model and improving learning engagement. Methods Student engagement and related data were obtained through a questionnaire survey, and multiple linear regression models were used to analyze the influencing factors of learning engagement. Results After implementing blended learning in the course, students showed high engagement scores in all six sub-dimensions and total learning engagement. Learning engagement was positively correlated with academic performance without significant statistical differences. Multiple linear regression analysis showed that students' self-efficacy, the presentation and delivery of resources, and the perceived gains were significantly positively correlated with learning engagement. Satisfaction with seven aspects of blended learning significantly influenced different sub-dimensions of learning engagement. Conclusion Blended learning effectively promotes students' engagement. When designing blended learning, attention should be paid to the selection of teaching platforms, reconstruction of teaching content, development of online teaching resources, training of teachers' teaching abilities, and the objective design and interpretation of process evaluation indicators.