The course teaching team proposed a teaching model of project-based learning (PBL) combined with massive open online courses (MOOC) based on the current situation and existing problems of graduate medical statistics teaching. This article provides a detailed explanation of the implementation process of this new teaching model in graduate medical statistics courses. A comparative analysis was conducted on its effectiveness, and the results showed that the PBL combined with MOOC teaching mode has advantages in improving students' learning interest and motivation, expanding learning resources and paths. Moreover, complementing and integrating with traditional teaching modes is an effective way to solve the current difficulties in learning medical statistics courses for graduate students. It provides new ideas for the teaching reform and practice of other courses for medical graduate students.