This paper adopts the inter-college cooperation training mode, integrates sections of the lesson plans for Fundamentals of Disease-Medical Microbiology and Clinical Laboratory Microbiology on pathogen-related detection techniques, introduces the joint teaching mode of university-enterprise alliance, develops the systematic Clinical Laboratory Microbiology curriculum keeping up with the times, combines with the concept of "One Health", and gives full play to the characteristics of the disciplines. Social practice activities are organized, and the goal of cultivating morality and education is carried out through the whole process of education, so as to cultivate innovative talents in health science and technology for the needs of the new medical science and the times.