Ocular fundus disease is one of the most complex fields in ophthalmology, and it is also the focus and difficult point of ophthalmology learning. Ocular fundus imaging is an important means and reliable method in the diagnosis and treatment,teaching and learning ocular fundus diseases. The development of fundus imaging has entered the multimodal era. In recent years, multimodal fundus imaging has achieved multiple integration of different images, and point to point accurate alignment between different images; not only the interactive fusion of planar and stereoscopic images, but also the organic combination of structural and functional image. Applying multi-modal imaging in teaching of ocular fundus diseases is more efficient to comprehensive and profound understanding and mastery of fundus diseases. In view of the existing problems in the current teaching, combined with the actual needs, this paper puts forward to take fundus diseases as center, to take the pathological mechanisms as basis, with the evidence-based interpretation of fundus multimodal images as the main teaching means to enable students to master fundus diseases effectively. Meanwhile, this research will improve teaching methods, and adopt the guided teaching model in which the basis of disease and imaging manifestations mutually understand and support each other, so to stimulate students' enthusiasm for independent learning, improve teaching efficiency, and improve students' logical and dialectical clinical thinking skills.