实现高水平的科技自立自强不仅是国家强盛之基、安全之要，也是应对国际环境变化的必然选择。实现高水平科技自立自强，需要坚持自主创新与开放创新相结合的原则；需要坚持问题导向与目标导向相结合的原则；需要坚持基础研究与应用研究相结合的原则。在追求高水平科技自立自强的过程中，我国已经采取了一系列实践措施，包括增加对基础研究的财政投入、建设高水平的科研支撑平台、加强人才队伍的建设以及广泛开展国际科学合作交流。实现高水平科技自立自强，就要坚持以党的领导为根本保证，坚持以国家战略需求为主要导向，坚持以人才为第一资源，坚持以开放合作。这些经验为进一步提高科技创新水平，构筑国家竞争优势，实现高水平的科技自立自强提供了可行的路径。

Achieving high-level scientific and technological self-reliance is not only the cornerstone of a strong country, but also an inevitable choice in response to changes in the international environment. To achieve high-level scientific and technological self-reliance, we need to follow three basic principles: Adhere to the principle of combining independent innovation with open innovation, adhere to the principle of combining problem orientation with goal orientation, and adhere to the principle of combining basic research with applied research. In the process of pursuing high-level scientific and technological self-reliance, our country has adopted a series of practical measures, including increasing financial investment in basic research, building a high-level basic research support platform, strengthening the construction of basic research talent teams, and conducting extensive basic research international collaboration in research. To achieve high-level scientific and technological self-reliance, we must adhere to the party's leadership as the fundamental guarantee, adhere to the national strategic needs as the main orientation, adhere to talent as the first resource, and adhere to open cooperation as the basic approach. These experiences provide a feasible path to further improve the level of scientific and technological innovation and achieve high-level scientific and technological self-reliance.