Implementing talent cultivation as the core, creating a diversified classroom with a hybrid teaching mode of online and offline under the‘Internet+’background and constructing a student-centered teaching system have become the core tasks of educational teaching reform in colleges and universities at this stage. Aiming at the students of the applied clinical pharmacy major, with the goal of cultivating ‘evidence-based thinking that follows clinical evidence and takes actual therapeutic effect as the standard,’ we explore the classroom reform of "online and offline integration + multiple methods + whole-process evaluation" to achieve the transformation from ‘teacher-led’ to ‘student-centered’, from ‘single teaching method’ to ‘multi-channel independent learning’, from ‘terminal assessment’ to ‘emphasizing whole process’. This enables students to deeply implant and preliminarily apply evidence-based thinking in the process of autonomous learning, autonomous thinking, daring to question, and daring to explore, ultimately enhancing the comprehensive quality and professional competence of talent cultivation in the clinical pharmacy major.