Virtual simulation experiment teaching is a digital teaching mode that relies on simulation technology and virtual reality technology. Traditional university chemistry experiment teaching has issues such as high requirements for practical operation environments and high operational costs. With the support of virtual simulation technology, students can easily perform experimental operations in a realistic virtual environment, learn chemical experimental skills and knowledge, while avoiding personal danger and resource waste that may arise from real operations. As one of the largest knowledge network platforms in China, China National Knowledge Infrastructure (CNKI) provides sufficient and effective data support for literature research. This paper has collected and organized relevant literature materials on the application of virtual simulation technology in the field of chemical experiment teaching from 2010 to 2022, and has conducted a statistics analysis of current development status, hot topics, and trends of virtual simulation experiment teaching in Chinese university chemistry course through the literature data visualization software CiteSpace. The study shows that virtual simulation technology has been widely applied and rapidly developed in chemical experiment teaching, and the integration of virtual simulation teaching into university chemistry teaching has become the current trend of development.