目的 为比较研究临床上常用药物对鸡沙门氏菌病的治疗效果，筛选出合理治疗药物，避免抗生素的盲目使用。 方法 将具有清热解毒和一定抗菌消炎的复方中药组方优化后与硫酸卡那霉素、恩诺沙星、氯霉素、磺胺甲恶唑进行药敏试验和治疗比较试验。 结果 磺胺甲恶唑，高敏感株占比达86.6%，治愈率达86%；复方中药高敏感株占比73.4%，治愈率76%；硫酸卡那霉素、氯霉素高敏感株占比分别为80%、76.7%，略高于复方中药，治愈率分别为64%、66%，低于复方中药组；恩诺沙星高敏感株占比为56.7%，治愈率为58%，效果较差。 结论 复方中药对沙门氏菌有一定的抑菌和抗菌作用，中西药结合对疾病有很好的治疗和预防作用。

Objectives The therapeutic effects of commonly used drugs on Salmonella in chicken were compared and the reasonable therapeutic drugs were screened out to avoid the blind use of antibiotics. Methods The compound traditional Chinese medicine formula with heat clearing, detoxification and certain antibacterial and anti-inflammatory properties were optimized. The tests of drug sensitivity and treatment comparison of optimized compound traditional Chinese medicine formula with kanamycin sulfate, enrofloxacin, chloramphenicol, and sulfamethoxazole were carried out. Results The highly sensitive strain against sulfamethoxazole accounted for 86.6%, with a cure rate of 86%. The highly sensitive strains against compound traditional Chinese medicine accounted for 73.4%, with a cure rate of 76%. The proportion of highly sensitive strains against kanamycin sulfate and chloramphenicol was 80% and 76.7%, slightly higher than that of the compound Chinese medicine, with a cure rate of 64% and 66%, lower than that of the compound Chinese medicine group. The proportion of highly sensitive strains against enrofloxacin was 56.7%, with a cure rate of 58%, indicating that the effect is poor. Conclusions It is indicated that the compound Chinese medicine has certain antibacterial and anti-inflammatory effects on Salmonella, and the combination of Chinese and Western medicine has good therapeutic and preventive effects on diseases.