纳米复合材料基智能创伤敷料在创面修复领域的研究进展

赵寿森, 刘兆麟, 魏玉娟, 蔡红伟

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中国高校科技期刊信息汇聚平台
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塑料科技 ›› 2025, Vol. 53 ›› Issue (01) : 157-162. DOI: 10.15925/j.cnki.issn1005-3360.2025.01.029
综述

纳米复合材料基智能创伤敷料在创面修复领域的研究进展

作者信息 +

Research Progress on Nanocomposite-based Smart Wound Dressings in Wound Repair Field

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History +

摘要

传统创伤敷料存在难以对伤口状态进行实时监测、不具备感染预警作用、无法按需释药以满足伤口愈合动态需求等问题，限制其在创面修复领域的应用。纳米复合材料基智能创伤敷料通过添加自响应材料，能够感知伤口状况和环境变化并予以及时反馈，成为创伤敷料领域的研究热点。文章探讨纳米复合材料基智能创伤敷料的制备方法，基于温度、pH值、活性氧、葡萄糖等不同的刺激响应体系综述纳米复合材料基智能创伤敷料的研究进展，介绍其在药物释放、伤口监测等领域的应用。最后，从生物安全性、结构功能稳定性、灵敏度和准确性等方面对纳米复合材料基智能创伤敷料的发展趋势进行展望。

Abstract

Traditional wound dressings have limitations in real-time monitoring of wound status, lack of infection warning function, and inability to release drugs according to the dynamic needs of wound healing, which have hindered their application in wound healing field. Nanocomposite-based smart wound dressings can sense wound conditions, environmental changes and provide timely feedback by the addition of self-responsive materials, becoming a research hotspot in the field of wound dressings. The preparation methods of nanocomposite-based smart wound dressings are discussed. The research progress of nanocomposite-based smart wound dressings in terms of different stimulus response systems are summarized, including temperature, pH value, active oxygen and glucose response. Their applications in drug release and wound monitoring are introduced. Finally, the development trend of nanocomposite-based smart wound dressings is prospected from the perspectives of biosafty, structural and functional stability, sensitivity and accuracy.

关键词

纳米复合材料 / 智能创伤敷料 / 响应体系 / 药物释放

Key words

Nanocomposites / Smart wound dressing / Response system / Drug release

中图分类号

TB332

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导出引用
赵寿森 , 刘兆麟 , 魏玉娟 , 等. 纳米复合材料基智能创伤敷料在创面修复领域的研究进展. 塑料科技. 2025, 53(01): 157-162 https://doi.org/10.15925/j.cnki.issn1005-3360.2025.01.029
ZHAO Shousen, LIU Zhaolin, WEI Yujuan, et al. Research Progress on Nanocomposite-based Smart Wound Dressings in Wound Repair Field[J]. Plastics Science and Technology. 2025, 53(01): 157-162 https://doi.org/10.15925/j.cnki.issn1005-3360.2025.01.029

参考文献

列表( 原文顺序 | 文献年度倒序 | 文中引用次数倒序 ) 可视化分析
1
葛世荣.智能表面工程[J].中国表面工程,2024,37(1):1-17.
本文引用 [1]
2
DAVIS M, HOM D. Current and future developments in wound healing[J]. Facial Plastic Surgery, 2023, 39(5): 477-488.
本文引用 [1]
3
FARAHANI M, SHAFIEE A. Wound healing: From passive to smart dressings[J]. Advanced Healthcare Materials, 2021, DOI: 10.1002/adhm.202100477.
本文引用 [1]
4
尹祖秀,黄婷婷,王建英,等.pH响应型抗菌水凝胶伤口敷料的制备及促愈合性能[J].高分子材料科学与工程,2024,40(4):29-39.
本文引用 [1]
5
DONG R N, GUO B L. Smart wound dressings for wound healing[J]. Nanotoday, 2021, DOI: 10.1016/j.nantod.2021.101290.
本文引用 [1]
6
王一如,白姣姣.微环境pH值对慢性创面愈合影响的研究进展[J].护理学杂志,2023,38(19):121-124.
本文引用 [1]
7
PAULA C T B, SARAIVA S, PEREIRA P, et al. ROS-responsive electrospun poly(amide thioketal) mats for wound dressing applications[J]. Polymer, 2024, DOI: 10.1016/j.polymer.2024.126697.
8
张颖,李静.系统化护理干预对结直肠癌合并2型糖尿病患者术后切口愈合的影响[J].糖尿病新世界,2024,27(1):117-120.
本文引用 [1]
9
DONG Y P, FU S J, YU J Y, et al. Emerging smart micro/nanofiber-based materials for next-generation wound dressings[J]. Advanced Functional Materials, 2023, DOI: 10.1002/adfm.202311199.
本文引用 [1]
10
刘科,钟志成,乔辉.纺丝参数对PS纳米纤维形态和直径的影响[J].塑料科技,2020,48(4):51-54.
本文引用 [1]
11
陈淑花,孙婷婷,于驰,等.氧化微晶纤维素-壳聚糖薄膜状敷料制备与表征[J].工程塑料应用,2020,48(8):28-35.
本文引用 [1]
12
杨晓晓,柳毅浩,王成伟,等.酚红修饰ε-L-聚赖氨酸/聚乙二醇二缩水甘油醚凝胶敷料配伍绿原酸用于伤口pH检测[J].中医药导报, 2022,28(2):13-16, 29.
本文引用 [1]
13
ZHANG P R, XU X M, HE W M, et al. Autocatalytically hydroxyl-producing composite wound dressing for bacteria-infected wound healing[J]. Nanomedicine: Nanotechnology, Biology and Medicine, 2023, DOI: 10.1016/j.nano.2023.102683.
本文引用 [1]
14
杨超,邹杰,李鉴墨.静电纺丝制备高度取向胶原纤维及其性能研究[J].高分子通报,2024,37(7):956-966.
本文引用 [1]
15
KEIROUZ A, WANG Z, REDDY V S, et al. The history of electrospinning: past, present, and future developments[J]. Advanced Materials Technologies, 2023, DOI: 10.1002/admt.202201723.
16
王金霞.聚苯乙烯衍生物/碳纳米纤维复合材料的制备与电容去离子研究[J].塑料科技,2020,48(9):23-26.
本文引用 [1]
17
BAHRAMI F, ESLAHI N, JAHANMARDI R. Electrospinning of smart nanofibers based on PVP/PDA for wound dressing applications[J]. The Journal of the Textile Institute, 2023, DOI: 10.1080/00405000.2023.2268828.
本文引用 [1]
18
HU Q X, HUANG Z W, ZHANG H G, et al. Preparation and characterization of nano-silver-loaded antibacterial membrane via coaxial electrospinning[J]. Biomimetics, 2023, DOI: 10.3390/biomimetics8050419.
本文引用 [1]
19
FANG S K, LI H R, FENG S D, et al. Preparation of PAN@PU coaxial electrostatic spun nanofibers for oil/water separation[J]. Journal of Applied Polymer Science, 2023, DOI: 10.1002/app.54973.
20
任婕,刘太奇,郑玄之,等.同轴静电共喷纺及其在锂离子电池复合隔膜改性中的应用[J].高分子材料科学与工程,2024,40(3):125-132.
本文引用 [1]
21
RIVERO G, MEUTER M, PEPE A, et al. Nanofibrous membranes as smart wound dressings that release antibiotics when an injury is infected[J]. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2020, DOI: 10.1016/j.colsurfa.2019.124313.
本文引用 [1]
22
TSEGAY F, ELSHERIF M, BUTT H. Smart 3D printed hydrogel skin wound bandages: A review[J]. Polymers, 2022, DOI: 10.3390/polym14051012.
本文引用 [1]
23
尚祖明,胡成女.3D打印PETG的工艺、改性及应用研究进展[J].塑料科技,2024,52(3):121-126.
24
LI R, ZHANG L, JIANG X B, et al. 3D-printed microneedle arrays for drug delivery[J]. Journal of Controlled Release, 2022, 350: 933-948.
本文引用 [1]
25
COJOCARU E, GHITMAN J, PIRCALABIORU G G, et al. Electrospun/3D-printed bicomponent scaffold co-loaded with a prodrug and a drug with antibacterial and immunomodulatory properties[J]. Polymers, 2023, DOI: 10.3390/polym15132854.
本文引用 [1]
26
张旭阳,赵德杰,商铭溶,等.下肢深静脉血栓形成的中医辨证要素分析[J].中国中西医结合外科杂志,2024,8(39):1-4.
本文引用 [1]
27
PANEYSAR J S, BARTON S, AMBRE P, et al. Novel temperature responsive films impregnated with silver nano particles (Ag-NPs) as potential dressings for wounds[J]. Journal of Pharmaceutical Sciences, 2022, 111(3): 810-817.
本文引用 [1]
28
JIANG J, DING J, WU X Y, et al. Flexible and temperature-responsive hydrogel dressing for real-time and remote wound healing monitoring[J]. Journal of Materials Chemistry B, 2023, 11(22): 4934-4945.
本文引用 [1]
29
ZHANG K Y, LV H J, ZHENG Y Q, et al. Nanofibrous hydrogels embedded with phase-change materials: Temperature-responsive dressings for accelerating skin wound healing[J]. Composites Communications, 2021, DOI: 10.1016/j.coco.2021.100752.
本文引用 [1]
30
HAN Z Y, YUAN M J, LIU L B, et al. pH-responsive wound dressings: Advances and prospects[J]. Nanoscale Horizons, 2023, 8(4): 422-440.
本文引用 [1]
31
JIN S G. Production and application of biomaterials based on polyvinyl alcohol (PVA) as wound dressing[J]. Chemistry—An Asian Journal, 2022, DOI: 10.1002/asia.202200595.
本文引用 [1]
32
JIA J J, LIN Z H, ZHU J L, et al. Anti-adhesive and antibacterial chitosan/PEO nanofiber dressings with high breathability for promoting wound healing[J]. International Journal of Biological Macromolecules, 2024, DOI: 10.1016/j.ijbiomac.2024.129668.
本文引用 [1]
33
张进,兰龙宇,陈越军,等.静电纺制备负载美洛昔康聚己内酯纳米纤维膜[J].化学研究与应用,2023,35(12):2967-2974.
本文引用 [1]
34
YIN J, XU L, AHMED A. Batch preparation and characterization of electrospun porous polylactic acid-based nanofiber membranes for antibacterial wound dressing[J]. Advanced Fiber Materials, 2022, 4(4): 832-844.
本文引用 [1]
35
LIANG W Z, NI N, HUANG Y X, et al. An advanced review: Polyurethane-related dressings for skin wound repair[J]. Polymers, 2023, DOI: 10.3390/polym15214301.
本文引用 [1]
36
WU H Y, YAN S, WANG Y, et al. Preparation and properties of electrospun chitosan/polybutylenes succinate nanofiber membrane for wound hemostatic dressing[J]. Journal of Industrial Textiles, 2022, DOI: 10.1177/15280837221113086.
本文引用 [1]
37
ZHANG J Q, ZHANG S W, LIU C, et al. Photopolymerized multifunctional sodium alginate-based hydrogel for antibacterial and coagulation dressings[J]. International Journal of Biological Macromolecules, 2024, DOI: 10.1016/j.ijbiomac.2024.129428.
本文引用 [1]
38
BOZER B M, ÖZKAHRAMAN B, MERT H. Photocrosslinked methacrylated pectin and methacrylated hyaluronic acıd wound dressing loaded with oleuropein as bioactive agent[J]. International Journal of Polymeric Materials and Polymeric Biomaterials, 2023, 73(11): 961-973.
本文引用 [1]
39
DU M, JIN J, ZHOU F, et al. Dual drug-loaded hydrogels with pH-responsive and antibacterial activity for skin wound dressing[J]. Colloids and Surfaces B: Biointerfaces, 2023, DOI: 10.1016/j.colsurfb.2022.113063.
本文引用 [1]
40
LOTFINIA F, NOROUZI M R, GHASEMI M L, et al. Anthocyanin/honey-incorporated alginate hydrogel as a bio-based pH-responsive/antibacterial/antioxidant wound dressing[J]. Journal of Functional Biomaterials, 2023, DOI: 10.3390/jfb14020072.
本文引用 [1]
41
HUANG C, DONG L L, ZHAO B H, et al. Anti-inflammatory hydrogel dressings and skin wound healing[J]. Clinical and Translational Medicine, 2022, DOI: 10.1002/ctm2.1094.
本文引用 [1]
42
PANG Q, YANG F, JIANG Z L, et al. Smart wound dressing for advanced wound management: real-time monitoring and on-demand treatment[J]. Materials and Design, 2023, DOI: 10.1016/j.matdes.2023.111917.
本文引用 [1]
43
王昌海,张馨雨,焦煜雯,等.活性氧/谷胱甘肽双重响应型紫杉醇前药纳米粒的制备与评价[J].中国现代应用药学,2023,40(17):2414-2426.
44
聂渡,邵俊俊,颜子健,等.清除活性氧用丝素水凝胶[J].功能高分子学报,2024,37(2):102-112.
本文引用 [1]
45
RUI J Z, PENG H H, GUAN Y X, et al. Preparation of ROS-responsive drug-loaded hydrogels applied in wound dressings using supercritical solvent impregnation[J]. The Journal of Supercritical Fluids, 2022, DOI: 10.1016/j.supflu.2022.105682.
本文引用 [1]
46
YE J, LI Q H, ZHANG Y S, et al. ROS scavenging and immunoregulative EGCG@Cerium complex loaded in antibacterial polyethylene glycol-chitosan hydrogel dressing for skin wound healing[J]. Acta Biomaterialia, 2023, 166: 155-166.
本文引用 [1]
47
PAULA C T B, MADEIRA A B, PEREIRA P, et al. ROS-degradable PEG-based wound dressing films with drug release and antibacterial properties[J]. European Polymer Journal, 2022, DOI: 10.1016/j.eurpolymj.2022.111447.
本文引用 [1]
48
李向梅,刘娟,莫希.基于循证依据的血糖管理模式在危重症患者血糖管理中的应用[J].齐鲁护理杂志,2023,29(23):118-121.
本文引用 [1]
49
王洋琛,耿若愚,杨建华,等.基于网络药理学和实验验证探讨三七总皂苷治疗糖尿病肾病的作用机制研究[J].中国中药杂志,2024,49(17):4607-4616.
本文引用 [1]
50
ZHU W, LIU Y Q, LIU P, et al. Blood-glucose-depleting hydrogel dressing as an activatable photothermal/chemodynamic antibacterial agent for healing diabetic wounds[J]. ACS Applied Materials and Interfaces, 2023, 15(20): 24162-24174.
本文引用 [1]
51
BHADAURIYA P, MAMTANI H, ASHFAQ M, et al. Synthesis of yeast-immobilized and copper nanoparticle-dispersed carbon nanofiber-based diabetic wound dressing material: Simultaneous control of glucose and bacterial infections[J]. ACS Applied Bio Materials, 2018, 1(2): 246-258.
本文引用 [1]
52
秦杰,耿鑫,靳开朗,等.聚乳酸/rGO/HTPDMS纳米纤维膜制备及其性能研究[J].塑料科技,2024,52(4):19-22.
本文引用 [1]
53
王红伟,王立红,刘泽梅,等.载黄芪甲苷的核壳结构纳米纤维创面敷料的制备及性能[J].功能高分子学报,2024,37(4):338-346.
本文引用 [1]
54
LIU X N, ZHANG Y J, LIU Y J, et al. Injectable, self-healable and antibacterial multi-responsive tunicate cellulose nanocrystals strengthened supramolecular hydrogels for wound dressings[J]. International Journal of Biological Macromolecules, 2023, DOI: 10.1016/j.ijbiomac.2023.124365.
本文引用 [1]
55
TIWARI R, PATHAK K. Local drug delivery strategies towards wound healing[J]. Pharmaceutics, 2023, DOI: 10.3390/pharmaceutics15020634.
本文引用 [1]
56
YANG Y T, LI M, PAN G Y, et al. Multiple stimuli-responsive nanozyme-based cryogels with controlled NO release as self-adaptive wound dressing for infected wound healing[J]. Advanced Functional Materials, 2023, DOI: 10.1002/adfm.202214089.
本文引用 [1]
57
DONG D, CHEN R M, JIA J H, et al. Tailoring and application of a multi-responsive cellulose nanofibre-based 3D nanonetwork wound dressing[J]. Carbohydrate Polymers, 2023, DOI: 10.1016/j.carbpol.2023.120542.
本文引用 [1]
58
CHEN R M, ZHAO C, CHEN Z P, et al. A bionic cellulose nanofiber-based nanocage wound dressing for NIR-triggered multiple synergistic therapy of tumors and infected wounds[J]. Biomaterials, 2022, DOI: 10.1016/j.biomaterials.2021.121330.
本文引用 [1]
59
赵琦,袁凤来,陈明清,等.载有左氧氟沙星的普鲁兰多糖薄膜用于伤口敷料[J].功能高分子学报,2023,37(2):138-147.
本文引用 [1]
60
WANG L R, ZHOU M Y, XU T L, et al. Multifunctional hydrogel as wound dressing for intelligent wound monitoring[J]. Chemical Engineering Journal, 2022, DOI: 10.1016/j.cej.2022.134625.
本文引用 [1]
61
ESKILSON O, ZATTARIN E, BERGLUND L, et al. Nanocellulose composite wound dressings for real-time pH wound monitoring[J]. Materials Today Bio, 2023, DOI: 10.1016/j.mtbio.2023.100574.
本文引用 [1]
62
WANG Z, OU X L, GUAN L, et al. Pomegranate-inspired multifunctional nanocomposite wound dressing for intelligent self-monitoring and promoting diabetic wound healing[J]. Biosensors and Bioelectronics, 2023, DOI: 10.1016/j.bios.2023.115386.
本文引用 [1]

基金

国家自然科学基金青年科学基金项目(51804096)
河北省科技特派员企业科技特派员项目(2702)

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