以N-异丙基丙烯酰胺（NIPAM）为单体、过硫酸铵（APS）为氧化剂、四甲基乙二胺（TEMED）为还原剂、含有在还原性条件下可降解的二硫键的N，N’-双（丙烯酰）胱胺（BAC）为交联剂、二甲基甲酰胺（DMF）为溶解BAC的溶剂，利用无皂乳液聚合法，通过APS与TEMED的氧化还原引发体系，成功制备BAC交联的聚（N-异丙基丙烯酰胺）（PNIPAM）微凝胶。傅里叶变换红外光谱仪（FTIR）测试显示，微凝胶中含有二硫键；透射电子显微镜（TEM）结果显示，产物微凝胶为亚微米尺寸的规整球形；动态光散射（DLS）结果显示，微凝胶具有明显的温度敏感性，体积相转变温度（VPTT）在29.1 ℃左右。BAC交联的PNIPAM微凝胶在还原剂二硫苏糖醇（DTT）水溶液中表现出明显的降解性能，且DTT浓度越大，微凝胶的降解速度越快，降解程度越大。

Using N-isopropylacrylamide (NIPAM) as the monomer, ammonium persulfate (APS) as the oxidizing agent, tetramethylethylenediamine (TEMED) as the reducing agent, N,N'-bis(acryloyl) cystamine (BAC) containing reducible disulfide bonds under reductive conditions as the crosslinking agent, and dimethylformamide (DMF) as the solvent for dissolving BAC, the study successfully prepared BAC-crosslinked poly(N-isopropylacrylamide) (PNIPAM) microgels through a soap-free emulsion polymerization method, utilizing the redox initiation system of APS and TEMED. The FTIR test showed that the microgels contained disulfide bonds. The product microgels were observed to be regular spheres with submicron dimensions by TEM. The microgels were observed to be significantly temperature-sensitive by DLS, with the volumetric phase-transition temperatures (VPTT) around 29.1 ℃. The BAC-crosslinked PNIPAM microgels in aqueous solution of the reductant dithiothreitol (DTT) showed an obvious degradation property, and the larger the concentration of DTT, the faster and greater the degradation of the microgel.