目的 拟建立一种将自主最大笑容（AMS）三维面像与数字化三维牙列模型整合的方法，以实现在三维面像背景下显示数字化正畸终末位设计的目的。 方法 利用Geomagic Studio软件，通过手动注册和全局注册功能，将AMS三维面像和初始牙列模型进行配准对齐，然后用终末位牙列模型在原位替换初始牙列模型，并去除AMS三维面像口内区域，从而实现AMS三维面像和终末位牙列模型的融合显示。计算AMS三维面像和初始牙列模型上4组对应标志点对间的距离，通过配对t检验评估配准操作的准确性。 结果 该方法成功实现了AMS三维面像与初始、终末三维牙列模型的整合。两次配准对齐后，点对间的平均距离分别为（1.19±0.55）mm和（1.55±0.59）mm。两次测量结果的差异无统计学意义（P>0.05），且具有很高的一致性（组内相关性系数=0.914）。 结论 本研究建立了AMS三维面像与数字化初始、终末三维牙列模型整合的方法。该方法具有较高的准确性，有助于实现在三维面像背景下数字化正畸终末位设计效果的显示，从而提升以隐形正畸为代表的数字化正畸终末位设计的质量。

Objective This study aims to establish an approach to integrate autonomous maximal smile (AMS) 3D facial image with digital 3D dental models to demonstrate the digital orthodontic set-up in the 3D facial context. Methods Using Geomagic Studio software, the AMS 3D facial image and pre-treatment dental model were manually and globally registered. Subsequently, the pre-treatment dental model was substituted with the predicted post-treatment dental model. The intraoral region of the AMS 3D facial image was removed, achieving a conjunctive display of the AMS 3D facial image and the post-treatment dental set-up. The distances between four groups of corresponding landmark pairs on the AMS 3D facial image and the pre-treatment dental set-up were calculated, and the accuracy of the registration operation was evaluated by paired t-test. Results The novel approach effectively facilitated the integration of AMS 3D facial images with the pre-treatment and predicted post-treatment 3D dental models. The average distances between the pairs of points were (1.19±0.55) mm and (1.55±0.59) mm for the two registrations, respectively. Notably, no statistically significant difference was observed between the two measurements (P>0.05), indicating a high agreement (intraclass correlation coefficient=0.914). Conclusion This study established an approach to integrate AMS 3D facial images with digital 3D dental models. Through this approach, the digital orthodontic set-up design can be displayed in the context of a 3D facial image, which may help to improve the quality of outcome set-up in digital orthodontics, such as clear aligner therapy.