目的 比较抗菌光动力疗法（aPDT）与全身抗菌药物辅助治疗牙周炎的疗效。 方法 搜索Embase、PubMed、Web of Science、Cochrane Library、中国知网、万方数据库、维普数据库共7个数据库，搜索时间从建库至2023年11月止，被搜索文献的语言类型为中文或英文。根据纳入排除标准筛选文献。用Cochrane工具进行文献质量评价。用 RevMan 5.4软件和Stata 14.0软件对被纳入的文献进行Meta分析和发表偏倚检测。 结果 共有8篇文献被纳入。Meta分析结果表明，治疗后3个月时，当光敏剂（PS）为亚甲基蓝（MB）时，龈下刮治和根面平整术（SRP）+aPDT对探诊深度（PD）的改善效果优于SRP+全身抗菌药物；治疗后3个月时，当PS为吩噻嗪氯时，SRP+全身抗菌药物对PD的改善效果优于SRP+aPDT（P<0.05）。治疗后3个月，SRP+aPDT/SRP+全身抗菌药物对临床附着水平（CAL）、探诊出血（BOP）的改善效果均无明显区别（P>0.05）；治疗后6个月，SRP+aPDT/SRP+全身抗菌药物对PD、CAL、BOP的改善效果均无明显区别（P>0.05）。与基线期相比，治疗后3个月时，SRP+aPDT使PD、CAL、BOP分别改善了（0.80±0.19） mm、（0.94±0.29）mm、19.74%±1.91%（P<0.05）；而SRP+全身抗菌药物使PD、CAL、BOP分别改善了（1.02±0.27）mm、（0.95±0.25） mm、19.39%±11.83%（P<0.05）。治疗后6个月，SRP+aPDT使PD、CAL、BOP分别改善了（1.37±0.47） mm、（1.29±0.52） mm、28.97%± 2.43%（P<0.05）；而SRP+全身抗菌药物使PD、CAL、BOP分别改善了（1.55±0.53） mm、（1.34±0.49） mm、29.34%± 10.47%（P<0.05）。 结论 SRP+MB-aPDT对PD的改善效果优于SRP+全身抗菌药物；SRP+全身抗菌药物对PD的改善效果优于SRP+吩噻嗪氯-aPDT，MB-aPDT或许能成为全身抗菌药物辅助治疗牙周炎的替代方法。牙周炎类型、2型糖尿病、吸烟、aPDT次数、全身抗菌药物的种类及其治疗时间等因素对于SRP+aPDT/SRP+全身抗菌药物的治疗效果影响相当。

Objective This study aimed to evaluate the efficacy of antimicrobial photodynamic therapy (aPDT) and systemic antimicrobial drug as an adjunct treatment for periodontitis. Methods 　Seven databases, namely, Embase, PubMed, Web of Science, Cochrane Library, CNKI, Wanfang, and VIP, were searched from inception until November 2023. The language of the searched literature is Chinese or English. Studies were screened out according to inclusion and exclusion criteria, and their quality was evaluated using the Cochrane tool. Meta-analysis and publication bias detection of the included studies were performed using RevMan 5.4 and Stata 14.0 software. Results Eight studies were included. Meta-analysis showed that 3 months after treatment using methylene blue (MB) as the photosensitizer (PS), the improvement effect of scaling and root planning (SRP)+aPDT on probing depth (PD) was better than that of SRP+systemic antimicrobial drug. When phenothiazine chloride was the PS, the improvement effect of SRP+systemic antimicrobial drug on PD was better than that of SRP+aPDT (P<0.05). No significant difference was observed in the improvement effect of SRP+aPDT/SRP+systemic antimicrobial drug on clinical attachment level (CAL) and probing bleeding (BOP) at 3 months after treatment (P>0.05) and the improvement effect of SRP+aPDT/SRP+systemic antimicrobial drug on PD, CAL, and BOP at 6 months after treatment (P>0.05). Compared with those at baseline, SRP+aPDT improved PD, CAL, and BOP by (0.80±0.19) mm, (0.94±0.29) mm, and 19.74%±1.91%, respectively, at 3 months after treatment (P<0.05). In addition, SRP+systemic antimicrobial drug improved PD, CAL, and BOP by (1.02±0.27) mm, (0.95±0.25) mm, and 19.39%±11.83%, respectively (P<0.05). At 6 months after treatment, SRP+aPDT improved PD, CAL, and BOP by (1.37±0.47) mm, (1.29±0.52) mm, and 28.97%±2.43%, respectively (P<0.05). In addition, SRP+systemic antimicrobial drug improved PD, CAL, and BOP by (1.55±0.53) mm, (1.34±0.49) mm, and 29.34%±10.47%, respectively (P<0.05). Conclusion For PD, the improvement effect is in the order of SRP+MB-aPDT>SRP+systemic antimicrobial drug> SRP+phenothiazine chloride-aPDT. MB-aPDT may be an alternative to systemic antimicrobial drug as an adjunct treatment for periodontitis. The type of periodontitis, type 2 diabetes mellitus, smoking, number of aPDT, type of systemic antimicrobial drug, and treatment time of systemic antimicrobial drug have a similar influence on the treatment effect of SRP+aPDT/SRP+systemic antimicrobial drug.