口臭在人群中一直有着较高的发病率，影响着世界上近一半的人口。随着人们的卫生意识提高，它成为人们社会交往中愈发关注和在意的问题。研究发现心理因素与口臭的发生发展有着较为密切的联系，焦虑、抑郁等负性情绪可能直接引起妄想性口臭的发病，同时它们也可以通过影响口腔菌群、牙周炎、唾液、免疫功能及系统性疾病等方面间接促进口内挥发性硫化物的生成。本文就近年来精神心理因素在口臭发病机制中的直接和间接相关性的研究进展作进行综述，以期提高临床医生的认识，对口臭患者的临床诊疗起到一定的启示作用。

Halitosis has always been prevalent in humans, affecting nearly half of the world's population. With the improvement of people’s health awareness, it has recently become a health concern among the public. Studies have shown that psychological factors were closely related to the occurrence and development of halitosis. Negative emotions such as anxiety and depression might directly lead to delusional halitosis while indirectly promoting the generation of volatile sulfur compounds in the oral cavity through affecting oral microbiota, periodontitis, saliva, immune function, and systemic diseases. This article provides a summary of research on direct and indirect correlations on the psychological factors in the pathogenesis of halitosis in recent years to improve the understanding of clinical doctors and provide some inspiration for the clinical diagnosis and treatment of patients with halitosis in the future.