Natural medicinal chemistry is a fundamental course in pharmacy-related majors. This study explores the integration of the "Learning from History" case teaching method and ideological and political education within this course. By incorporating historical elements such as course development, historical stories, expert contributions, and accumulated experiences, these materials serve as ideological and political components in teaching. This approach not only enhances students' interest in the course but also instills the spirit of scientific exploration and inspires them to dedicate themselves to the advancement of pharmaceutical science in China, ultimately achieving better teaching outcomes.