Political supervision is a major political issue in the new era and a powerful measure to ensure that the entire Party adheres to the centralized and unified leadership of the Party Central Committee. As the main base for talent cultivation, universities shoulder the sacred mission of cultivating talents for the Party and the country. Specific, precise, and normalized political supervision is not only the essential requirement for running a socialist university with Chinese characteristics well, but also an important guarantee for fulfilling the fundamental task of ideological education. Starting from the concept, purpose, and significance of political supervision, this paper aims to explore the weak links in university political supervision, identify the starting points of it, addresses these challenges by adopting a problem-oriented approach, remove barriers to the supervision process, promote the development of strict governance within the Party, and better use political supervision to ensure execution and improve development.