Basic Pathological Anatomy is a course that lies between basic medicine and clinical medicine, and plays an important role in the basic education of medicine and pharmacy. This paper explores the application of online and offline hybrid teaching mode in this course. Teaching resources have been improved, including pre-class study videos, pathology case analysis library, ideological and political education case library, digital slicing resource library, and a question bank for Basic Pathological Anatomy. Case teaching method, ideological and political education, flipped classroom and other teaching methods have been introduced. In addition, we have designed and implemented evaluation and assessment methods that are suitable for the hybrid courses, laying the foundation for further improving teaching quality.