Objective To explore the requirements for the quality of management talents, and provide suggestions for the cultivation of pharmaceutical management talents in universities from the perspective of supply and demand of universities and enterprises. Methods Based on the quality of managerial talents, a secondary indicator questionnaire was set up. Interviews and questionnaires were conducted online and offline with 50 college workers in related majors and 50 managers from pharmaceutical-related enterprises. The AHP (Analytic Hierarchy Process) method was used to construct an evaluation system for managerial talents, calculate the weight of each indicator, and use the fuzzy comprehensive evaluation method to calculate the scores of managerial talent requirements with pharmaceutical management as an example, exploring the differences between the two. Results The weights of the four major qualities calculated by the AHP method are as follows: political and moral quality 47% and 36%; professional quality 23% and 24%; psychological quality 18% and 25% and physical quality 12% and 16% for colleges and enterprises respectively. The top three secondary indicators of universities and enterprises and their weights are: political belief 29.14%, 14.76%; practical ability 17.25%, 12.24%; academic morality 9.40%, 13.32%. From the perspective of colleges and universities, the fourth and fifth places are daily behavior and functional quality; from the perspective of enterprises, the fourth and fifth places are professional knowledge and stress tolerance. According to the fuzzy comprehensive evaluation results, the scores of pharmaceutical management talents in universities and enterprises are 78.8 and 85.8 respectively. Conclusion There are differences between universities and enterprises in the evaluation of the quality of management talents. The transition of talents from colleges to enterprises is a continuous growth process. Universities should consider the needs of enterprises in the cultivation of management talents, combining practical, theoretical, and psychological qualities with the cultivation of political and moral quality to cultivate high-quality talents who not only have high moral conduct but also better meet the needs of enterprises.