PDF(490 KB)
Application of successful cases of me-too drugs in China in the teaching of drug design
ZHANG Tingjian, LIANG Jingwei, WANG Lin, SUN Qi, HAO Shuang, ZHAO Nan, MENG Fanhao
PDF(490 KB)
PDF(490 KB)
Application of successful cases of me-too drugs in China in the teaching of drug design
Higher medical education bears the significant historical mission of accelerating knowledge innovation and training pharmaceutical talents. With the development of pharmaceutical disciplines in China and the transition of drug research and development strategies from imitation to innovation, drug design has become one of the compulsory courses for pharmaceutical-related majors. The authors try to use China’s successful me-too drugs as case study in the teaching of drug design to improve students' learning enthusiasm, initiative and creativity, and to develop their ability of innovation and solving practical problems.
me-too drugs; case study; drug design
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[1] 方浩. 药物设计学（第四版）[M]. 北京: 人民卫生出版社, 2023.
[2] 郭宗儒. 药物化学总论 (第二版) [M]. 北京: 中国医药科技出版社, 2003.
[3] 孟繁浩，余瑜. 药物化学（案例版，第二版）[M]. 北京: 科学出版社, 2016.
[4] ARONSON Jeffrey K, RICHARD Green A. Me-too pharmaceutical products: History, definitions, examples, and relevance to drug shortages and essential medicines lists[J]. Br J Clin Pharmacol, 2020; 86(11): 2114-2122.
[5] ANDARTAJI F, SUPARTA G B, MARCHABAN M. Correspondence analysis between me too drugs formulation with patent information and the analytical method (Case sstudy: amlodipine tablets - PT indofarma (PERSERO) Tbk.)[J]. J Manage Pharm Pract, 2018,7(4): 161-167.
[6] 陶秀梅, 董江萍, 黄蕾, 等. 刍议创新药物研发的生态环境与创新药物研发[J]. 中国药学杂志, 2016,51(7): 592-597.
[7] HE Xiaojian, ZENG Xiangpeng, JIANG Chuanshen, et al. Efficacy and safety of antofloxacin-based triple therapy for helicobacter pylori eradication failure in China[J]. Dig Dis Sci, 2022,67(1): 208-215.
[8] XU Fengyan, HUANG Jihan, HE Yingchun, et al. Population pharmacokinetics of moxifloxacin and its concentration-QT interval relationship modeling in Chinese healthy volunteers[J]. Acta Pharmacol Sin, 2017,38(11): 1580-1588.
[9] 郭宗儒. 国家1类新药艾瑞昔布的研制[J]. 中国新药杂志, 2012,21(3): 223-230.
[10] 李冰言, 徐祥均, 牟志芳, 等. 艾瑞昔布对离体培养膝骨关节炎软骨细胞的作用及机制[J]. 中国临床药理学杂志, 2022,38(15): 1800-1804.
[11] 董杰, 王可欣, 何文娟, 等. 艾瑞昔布对CYP2C9酶活性及mRNA和蛋白表达的影响[J]. 中国医院药学杂志, 2022, 42(11): 1112-1116.
[12] SHI Yuankai, SUN Yan, DING Cuimin, et al. China experts consensus on icotinib for non-small cell lung cancer treatment (2015 version)[J]. J Thorac Dis, 2020,7(10): E468-472.
[13] 陈丽萍, 潘平生, 刘雪梅. 盐酸埃克替尼对晚期肺腺癌患者的临床疗效评价[J]. 抗感染药学, 2015,12(5): 766-768.
[14] LI Y, LI XH, HUANG ZJ, et al. A randomized, double blind, placebo-controlled, multicenter phase II trial of allisartan isoproxil in essential hypertensive population at low-medium risk[J]. Plos One, 2015,10(2): e0117560.
[15] LIU Y, WANG H, CHENG Y , et al. A 26-week repeated-dose toxicity study of allisartan isoproxil in Sprague-Dawley rats[J]. Drug Chem Toxicol, 2013,36(4): 443-450.
[16] 段承阿鑫, 隋宾艳, 艾丹丹, 等. 阿利沙坦酯治疗原发性高血压的临床综合评价[J]. 中国合理用药探索, 2022(3): bn46-55.
[17] AILEEN Wai-Kiu Chan, SEK-YING Chair, JANET Wing-Hung Sit, et al. Case-based Web learning versus face-to-face learning: a mixed-method study on university nursing students[J]. J Nurs Res, 2016,24(1): 31-40.
[18] MAGJUKA R, LIU X. A case study of online MBA courses: Online facilitation, case-based learning, and virtual team[M]. IGI Global, 2017.
[19] 王琳, 孟繁浩. 案例式教学法在药物化学教学中的应用[J]. 中国高等医学教育, 2010(12): 92-93.
[20] 李卫华, 吴曾睿, 刘桂霞, 等. 药物设计学课程的建设和教学实践[J]. 化工高等教育, 2021,38(2): 47-50,136.
[21] 谢琼, 李炜, 叶德泳, 等. 案例讨论在创新型药物设计学教学实践中的应用[J]. 药学教育, 2014,30(4): 40-43.
[22] 李小彬. “四个自信”在高校思想政治教育中的融入路径探讨[J]. 知识经济, 2020(13): 139,141.
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