By analyzing the current situation and drawbacks of pharmaceutical care and communication skills course, this article proposes a pharmaceutical innovation and entrepreneurship education reform based on the project-oriented mode of "Internet + pharmaceutical services". Reform strategies are designed for teaching methods, teaching modes, assessment indicators, and teaching requirements. Pharmaceutical undergraduate students have engaged in innovation and entrepreneurship education practices. The practice results show that the reform has achieved good results, the students' understanding of pharmaceutical care and communication skills has been deepened, their awareness of innovation and entrepreneurship has been enhanced, and the innovation and entrepreneurship skills has been well trained.