On January 7, 2025, an M _W7.1 earthquake struck Dingri County, Shigatse City, Xizang Autonomous Region. The epicenter was located at the intersection of the southern segment of the Shenzha-Dingjie rift fault system and the South Tibetan detachment system, near the Dengmocuo fault. To investigate the seismogenic mechanism, slip distribution, and Coulomb stress disturbances of the earthquake, this study firstly utilized the Sentinel-1A data to obtain the coseismic deformation fields by InSAR (interferometric synthetic aperture rader) and POT (pixel offset tracking) techniques. Then, we employed the SDM program to invert the fault coseismic slip-distribution, and subsequently calculated the coseismic Coulomb stress disturbances with variable depth. The results indicate that the coseismic deformation of the Dingri earthquake is dominated by subsidence. The seismogenic fault strikes nearly north-south, with a dip angle of ~60°. The inverted coseismic slip-distribution suggests that the major rupture zone (slip >1 m) extends ~40 km in length and ~14 km in width. The maximum slip is approximately 4.45 m, occurring at a depth of ~4.33 km. The average rake angle is approximately ‒76.81°, indicating that this earthquake was predominantly a normal faulting event with a slight left-lateral strike-slip component. Taken the shear modulus at 30 GPa, the inverted seismic moment is about 3.53×10¹⁹ N·m, equivalent to the moment magnitude M _W7.0. Aftershocks predominantly happened around the periphery of the major slip zone. Additionally, the coseismic and postseismic Coulomb stress disturbances suggest significant increases (>10 kPa) in the southern segment of Shenzha-Dingjie fault, the eastern segment of Zanda-Lhaze-Qongdojiang fault, the central-eastern segment of Dagyiling-Ngamring-Rinbung fault, and the central segment of Yarlung Tsangpo fault. The future seismic hazards on these fault segments warrant heightened attention.