Research advances in the pathogenesis and pathophysiological manifestations of interstitial cystitis caused by urothelial cell pyroptosis

Pang Lei, Shuang Weibing

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Journal of Chongqing Medical University ›› 2025, Vol. 50 ›› Issue (04) : 426-431. DOI: 10.13406/j.cnki.cyxb.003820
Neurogenic Lower Urinary Tract Dysfunction and Pelvic Floor Functional Restoration Column

Research advances in the pathogenesis and pathophysiological manifestations of interstitial cystitis caused by urothelial cell pyroptosis

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Abstract

Pyroptosis is a proinflammatory form of regulated cell death that can lead to the activation of inactive cytokines and the cleavage of gasdermin D in cells. The main pathological outcome of inflammatory bladder disease is the loss of bladder compliance，and cell pyroptosis plays an important role in this process. Some studies have shown that cell pyroptosis is regulated by various mechanisms such as DNA methylation and mitochondrial DNA oxidative damage，which intervene in the biological behavior of bladder urothelial cells in interstitial cystitis and induce impairment of bladder compliance. Therefore，this article reviews the regulatory mechanisms of cell pyroptosis in interstitial cystitis and the potential role of pyroptosis in inflammatory bladder diseases，in order to explore potential diagnostic biomarkers for interstitial cystitis and facilitate the prevention and treatment of interstitial cystitis.

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interstitial cystitis / pyroptosis / DNA methylation / mitochondrial oxidative damage

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Pang Lei , Shuang Weibing. Research advances in the pathogenesis and pathophysiological manifestations of interstitial cystitis caused by urothelial cell pyroptosis. Journal of Chongqing Medical University. 2025, 50(04): 426-431 https://doi.org/10.13406/j.cnki.cyxb.003820

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