Research advances in the role and mechanism of tryptophan metabolism in tumor development and progression

Han Leng, Zhu Xinting, Zhang Jiayu, Guo Cheng, Yang Quanjun

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Journal of Chongqing Medical University ›› 2025, Vol. 50 ›› Issue (05) : 585-588. DOI: 10.13406/j.cnki.cyxb.003801
Precision Medicine in Cancer and Translational Studies

Research advances in the role and mechanism of tryptophan metabolism in tumor development and progression

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Abstract

Amino acids are essential nutrients for the survival of all cells in the body，and their metabolic processes are closely associated with tumor development and progression. The metabolic changes of the essential amino acid tryptophan have a significance impact on tumor microenvironment. Tryptophan is mainly metabolized to kynurenine （KYN） by indoleamine 2，3-dioxygenase and tryptophan 2，3-dioxygenase，and the accumulation of KYN and the deficiency of tryptophan cause alterations in the immune status in tumor microenvironment，which in turn affects tumor development and progression. Based on the current studies on tryptophan，this article systematically discusses the influence of abnormal tryptophan metabolism on tumors and the interventions targeting this pathway，in order to provide a reference for subsequent tumor therapy.

Key words

tryptophan metabolism / tumor development / tumor therapy / indoleamine 2，3-dioxygenase

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Han Leng , Zhu Xinting , Zhang Jiayu , et al . Research advances in the role and mechanism of tryptophan metabolism in tumor development and progression. Journal of Chongqing Medical University. 2025, 50(05): 585-588 https://doi.org/10.13406/j.cnki.cyxb.003801

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