Objective To investigate the efficacy and safety of a new airway opening device with automatic position adjustment. Methods From January 4 to March 15，2021，the purposive sampling method was used to select 360 patients who underwent bronchoscopy examination or treatment. According to the random sequence generated by a computer，the research assistant adjusted the position angle（PA） as 90°（90° PA group），95°（95° PA group），and 100°（100° PA group），respectively，to open the airway of subjects，and the bronchoscope entered the airway to obtain the image of the best glottic view. All subjects were followed up immediately after study and at 0.5，1，3，6，12，and 24 hours after study to observe device-related adverse events. The primary outcome measure was the Cormack-Lehane（CL） grade for glottic exposure，and the secondary outcome measures were the incidence rate of adverse events and Visual Analogue Scale（VAS） score. Results More than 80.0% of the subjects had CL grade I glottic exposure，and there was no significant difference in CL grade between the three PA groups（χ² =1.942，P>0.05）. The CL grade of some subjects was optimized at an angle of 100°. No device-related adverse events were reported，and the VAS score was 0. Conclusion The device can effectively and safely open the airway of subjects undergoing bronchoscopy at a PA of 90°-100°，and although it has no obvious advantage in improving glottic exposure at different levels of PA，it is recommended to select the PA of 100° to open the airway.