Febrile infection-related epilepsy syndrome

Wu Ye, Sang Tian, Guan Qian

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Journal of Chongqing Medical University ›› 2025, Vol. 50 ›› Issue (03) : 275-279. DOI: 10.13406/j.cnki.cyxb.003752
Febrile Infection-Related Epilepsy Syndrome Column

Febrile infection-related epilepsy syndrome

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Abstract

Febrile infection-related epilepsy syndrome is an inflammation-related acute encephalopathy that occurs in previously healthy children and adolescents. It is clinically characterized by super-refractory status epilepticus that occurs after a febrile infection and is often associated with poor prognosis. In recent years，with a deeper understanding of this disease，the treatment approaches have shifted to early and timely immunotherapy and comprehensive support on the basis of standardized anti-epileptic seizure treatment. This review comprehensively elaborates the definition，clinical characteristics，auxiliary examinations，pathogenesis，diagnosis and evaluation，treatment，prognosis，and future research directions of febrile infection-related epilepsy syndrome，aiming to enhance understanding and improve prognosis.

Key words

febrile infection-related epilepsy syndrome / new-onset refractory status epilepticus / infection-triggered encephalopathy syndrome

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Wu Ye , Sang Tian , Guan Qian. Febrile infection-related epilepsy syndrome. Journal of Chongqing Medical University. 2025, 50(03): 275-279 https://doi.org/10.13406/j.cnki.cyxb.003752

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