Objective To investigate the mid-term efficacy of Pulsar-18 stent in the treatment of spontaneous isolated superior mesenteric artery dissection（SIDSMA） through a retrospective analysis. Methods A retrospective analysis was performed for the data of patients with SIDSMA who received treatment with Pulsar-18 stent from April 2019 to March 2021. Basic information was collected，such as sex，age，underlying disease，and radiological features，and the patients were observed in terms of the improvement in clinical symptoms，stent patency rate，and vascular remodeling during follow-up. Results A total of 45 patients were included in this study，with 41 male patients and 4 female patients. The patients had an age of 45-72 years，and the patients with hypertension accounted for 48.89%（22/45）. The surgical success rate was 100%. A total of 63 stents were placed for the 45 patients，with a stent diameter ranging from 5 mm to 7 mm. There were no perioperative complications such as acute thrombosis of the stent，and the probability of hematoma at the puncture point was 0%. The stent patency rate was 100% at 3 months，6 months，1 year，and 2 years after stent placement，and the complete vascular remodeling rate was 64.4%，82.2%，82.2%，and 86.7%，respectively. One patient developed bloody stool at 5 months after surgery and was diagnosed with duodenal ulcer，and the patient fully recovered after endoscopic hemostasis. The other patients had no recurrent abdominal pain，new-onset aneurysms，or enlargement of the false lumen within 2 years. Conclusion Pulsar-18 stent placement is an effective treatment method for SIDSMA and can provide a high rate of complete vascular remodeling，with a high patency rate during mid-term follow-up.