Research advances in histone acetylation modification involved in oocyte senescence:from mechanism to drug

Chen Yuelu, Luo Xiaofang, Zhang Yue, Ma Jingmiao, Hu Zhongsheng, Wang Lianlian

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Journal of Chongqing Medical University ›› 2025, Vol. 50 ›› Issue (01) : 14-18. DOI: 10.13406/j.cnki.cyxb.003695
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Research advances in histone acetylation modification involved in oocyte senescence:from mechanism to drug

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Abstract

Female infertility is mostly associated with oocyte senescence,which is mainly caused by advanced maternal age and long waiting time before fertilization. These two different physiological processes exhibit similar epigenetic alterations,particularly in histone acetylation. Establishing an association between histone modification and human health and diseases is of great importance for intervening in disease development,developing novel clinical treatment regimens,and ultimately achieving disease cure. Therefore,this article elaborates on the changes in the profile of histone acetylation modifications associated with oocyte senescence and summarizes the potential targets for epigenetic therapy.

Key words

epigenetics / histone acetylation / oocyte senescence / advanced maternal age

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Chen Yuelu , Luo Xiaofang , Zhang Yue , et al . Research advances in histone acetylation modification involved in oocyte senescence:from mechanism to drug. Journal of Chongqing Medical University. 2025, 50(01): 14-18 https://doi.org/10.13406/j.cnki.cyxb.003695

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