
Research advances in histone acetylation modification involved in oocyte senescence:from mechanism to drug
Chen Yuelu, Luo Xiaofang, Zhang Yue, Ma Jingmiao, Hu Zhongsheng, Wang Lianlian
Research advances in histone acetylation modification involved in oocyte senescence:from mechanism to drug
Female infertility is mostly associated with oocyte senescence,which is mainly caused by advanced maternal age and long waiting time before fertilization. These two different physiological processes exhibit similar epigenetic alterations,particularly in histone acetylation. Establishing an association between histone modification and human health and diseases is of great importance for intervening in disease development,developing novel clinical treatment regimens,and ultimately achieving disease cure. Therefore,this article elaborates on the changes in the profile of histone acetylation modifications associated with oocyte senescence and summarizes the potential targets for epigenetic therapy.
epigenetics / histone acetylation / oocyte senescence / advanced maternal age
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