Association between pulmonary function and motor symptoms in patients with Parkinson’s disease

Yin Huimei, Cheng Oumei, Zhang Xu, Quan Fengying, Zhou Jianrong

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Journal of Chongqing Medical University ›› 2025, Vol. 50 ›› Issue (04) : 523-529. DOI: 10.13406/j.cnki.cyxb.003690
Clinical research

Association between pulmonary function and motor symptoms in patients with Parkinson’s disease

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Abstract

Objective To investigate the pulmonary function in patients with Parkinson’s disease（PD） and the association between pulmonary function and motor symptoms. Methods A total of 104 PD patients were included in the study，and a portable spirometer was used to assess pulmonary function. According to the results of pulmonary function，the patients were divided into ventilation dysfunction group with 37 patients and non-ventilation dysfunction with 67 patients，and clinical data were compared between the two groups. Univariate and multivariate logistic regression analyses were used to investigate the factors associated with abnormal pulmonary function，and a Spearman correlation analysis was used to investigate the correlation between pulmonary function parameters and motor symptoms. Results There were significant differences in the scores of bradykinesia and postural gait between the two groups（P<0.05），and the logistic regression analysis showed a positive correlation between pulmonary ventilation dysfunction and postural gait score（regression coefficient β=0.171，95%CI=1.015-1.386，P=0.032）. There were significant differences between the patients with different stages of PD in the pulmonary function parameters of the percentage of forced vital capacity in predicted value（t=2.143，P=0.034），the percentage of forced expiratory volume in 1 second（t=2.118，P=0.037），the percentage of predicted peak expiratory flow（t=2.002，P=0.048），maximum expiratory pressure as a percentage of predicted value（t=2.412，P=0.018），and maximum inspiratory pressure as a percentage of predicted value（t=2.119，P=0.036）. Conclusion The pulmonary function parameters of PD patients are lower than expected values，and the incidence rate of pulmonary ventilation dysfunction is 35.58%，with the main manifestation of restrictive ventilatory dysfunction. There is a correlation between pulmonary function and motor symptoms in PD patients.

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Parkinson’s disease / pulmonary function / related factors / cross-sectional study

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Yin Huimei , Cheng Oumei , Zhang Xu , et al . Association between pulmonary function and motor symptoms in patients with Parkinson’s disease. Journal of Chongqing Medical University. 2025, 50(04): 523-529 https://doi.org/10.13406/j.cnki.cyxb.003690

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