Objective To investigate the clinical healing status of supracondylar fracture of the humerus in children and related influencing factors，to establish a regression equation，and to predict the time to fracture healing. Methods A retrospective study was conducted among the children with supracondylar fracture of the humerus who underwent surgical treatment in Department of Orthopedics，Children’s Hospital of Chongqing Medical University，from June 1，2021 to May 30，2023，and related data were collected，including general status，diagnosis and treatment records，examination results，follow-up information，time to callus formation，and time to clinical fracture healing. SPSS 23.0 was used for univariate and multivariate analyses to establish a linear regression equation for callus formation and clinical fracture healing. Results A total of 251 children，aged 13-161 months，were enrolled in this study，with a mean age of （69.49±2.16） months，and there were 153 boys（60.96%） and 98 girls（39.04%）. There were 229 children with extension-type fracture（91.23%） and 22 with flexion-type fracture（8.76%）. The mean callus formation time was （17.21±5.73） days from fracture and （13.66±5.68） days from surgery，and the clinical fracture healing time was （46.67±13.52） days from fracture and （41.24±12.98） days from surgery. Callus formation was associated with the waiting time for surgery and total protein，and clinical fracture healing was associated with age in months（X₁），onset of fractures in autumn（X₂），waiting time for surgery（days） （X₃），fibrinogen （X₄），time of operation（minutes）（X₅），albumin，and fracture type. The multiple linear regression equation could predict 5.5% or 6.2% of callus formation time and 20.8% of clinical fracture healing time. The healing time of supracondylar fracture of the humerus in children（from the onset of fracture） Y=22.274＋0.118X₁-5.233X₂+0.047X₃+3.139X₄+0.058X₅（R²=0.225，adjusted R² =0.208，Durbin-Watson coefficient=1.953，F=13.528，P=0.001）. Conclusion Supracondylar fracture of the humerus in children often occurs in July to September，and the younger the age，the shorter the time to clinical fracture healing. The methods，such as shortening the waiting time for surgery，reducing fibrinogen，and shortening the time of operation，can help to shorten the time to clinical fracture healing. The regression equation can preliminarily predict the time to fracture healing to assist doctors and patients in arranging follow-up visits and the removal of devices，thereby avoiding long-term plaster fixation and multiple visits.