Involvement of spinal glial cells in the pathogenesis of chronic visceral pain

Wu Jing, Peng Tingting, Zhou Yong, Ke Jia, Zhuang Zhencheng, Chen Gang

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Journal of Chongqing Medical University ›› 2024, Vol. 49 ›› Issue (11) : 1356-1360. DOI: 10.13406/j.cnki.cyxb.003627
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Involvement of spinal glial cells in the pathogenesis of chronic visceral pain

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Abstract

Chronic visceral pain（CVP） is one of the common symptoms of many diseases triggered by underlying diseases in the visceral organs of the human body. Its causes include vascular mechanisms，mechanical factors，persistent inflammation，and unexplained functional mechanisms. Although the pathogenesis is unclear，more and more research has begun to shift from the neuronal aspect to glial cells in recent years. Spinal glial cells，particularly astrocytes and microglial cells，play an essential role in CVP. Based on this，this study elaborated on the mechanisms of action of astrocytes and microglial cells in CVP，including the release of cytokines，chemokines，and neuroactive substances and the alterations in intracellular signaling pathways. Because CVP is widespread in various diseases，drug treatments targeting astrocytes and microglial cells present broad application prospect.

Key words

chronic visceral pain / astrocyte / microglial cell / spinal dorsal horn / pathogenesis

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Wu Jing , Peng Tingting , Zhou Yong , et al . Involvement of spinal glial cells in the pathogenesis of chronic visceral pain. Journal of Chongqing Medical University. 2024, 49(11): 1356-1360 https://doi.org/10.13406/j.cnki.cyxb.003627

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