
Progress in protein ubiquitination
Zhou Menghan, Yang Yiping, Wang Shan
Progress in protein ubiquitination
Ubiquitination is one of the ways of post-translational modification in proteins,which performs mainly through seven lysine residues(K6,K11,K27,K29,K33,K48,K63) and one methionine residue(M1) of ubiquitin. It has been found that different ubiquitin linkages play important roles in regulating proteasomal degradation,DNA damage response,and antiviral immunity response. In this review,the roles of different types of ubiquitination modifications in tumorigenesis and viral infection,and the underline molecular mechanisms in recent years are summarized,aiming to provide reference for the functional study of different ubiquitin modification.
ubiquitination / ubiquitin modification / tumor / viral infection
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