
Research advances in the pathogenesis and clinical drug treatment of osteoporosis
Chen Changjun, Wang Qiuru, Zhao Xin, Ma Qingwei, Zhang Lei, Pan Xin, Kang Pengde
Research advances in the pathogenesis and clinical drug treatment of osteoporosis
Osteoporosis is a systemic metabolic bone disease,which can cause decreased bone density,bone microstructure destruction,and decreased bone strength,thus increasing the risk of fracture. With the aging of China’s population,an increasing number of patients are suffering from osteoporosis. This condition and its related complications continue to affect patients’ daily activities and reduce their quality of life. In recent years,global researchers have conducted increasingly in-depth research on this disease,leading to progress in its pathogenesis and clinical diagnosis and treatment. Literature search revealed that chronic liver and kidney dysfunction,alcohol consumption,and endocrine dysfunction can affect the development of osteoporosis by influencing bone metabolism. The Wnt signaling pathway,bone growth factor related signaling pathway,and RANKL/RANK/OPG signaling pathway are the key signaling pathways affecting the development of osteoporosis. Moreover,bisphosphonates and denosumab are commonly used drugs in the clinical treatment of osteoporosis. For individuals at high risk of osteoporotic fractures,bone-forming agents such as teriparatide and romosozumab can be considered. A rational sequence of drug therapy can help enhance the effectiveness of osteoporosis treatment. In this article,we will review the above advances to raise the awareness of clinicians and society about this disease,and help clinicians make better treatment decisions.
osteoporosis / pathogenesis / clinical drug treatment / research advances / review
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