Objective To investigate the clinicopathologic features and prognostic factors of nodal T-follicular helper cell lymphoma，angioimmunoblastic-type（nTFHL-AI）. Methods A retrospective analysis was performed for the clinical information of 63 patients with nTFHL-AI，and immunohistochemistry，in situ hybridization，and antigen receptor gene rearrangement were used to assess the clinicopathological features of nTFHL-AI. The Cox proportional hazards regression model was used to investigate prognostic factors. Results Immunostaining showed that the number of patients with dominant CD4-positive cells was significantly higher than that of patients with dominant CD8-positive cells（66% vs. 5%）. The patients who tested positive for Epstein-Barr virus-encoded small RNA （EBER） showed a higher probability for the expression of CXCL13 compared with their EBER-negative counterparts（P=0.006）. The 5-year overall survival（OS） rate and the progression-free survival（PFS） rate were 31% and 16%，respectively. The CXCL13-positive group had significantly better OS and PFS than the CXCL13-negative group（P=0.003 and 0.040）. On the contrary，positive BCL6 expression was associated with worse OS and PFS（P=0.026 and 0.044），and negative EBER was also associated with worse OS and PFS（P=0.013 and 0.047）. The multivariate analysis showed that negative EBER was an independent negative prognostic factor for both OS and PFS（P=0.001 and 0.003）. Conclusion Positive expression of CXCL13 indicates a favorable prognosis of nTFHL-AI patients，while positive BCL6 and negative EBER are associated with poor prognosis，and negative EBER is an independent risk factor for the prognosis of patients.