Objective To prepare MiCM@PFH@Lipid，a multifunctional liposome（Lipid） nanoparticles camouflaged with microglial cell membrane（MiCM） and loaded with the phase change material Perfluorohexane（PFH），to study its basic properties，and to test its ability to specifically target the site of injury after stroke and to achieve revascularization at the site of thrombus. Methods Liposome sphere carriers were prepared by rotary evaporation method. MiCM and PFH were fused with the liposome to form MiCM@PFH@Lipid using the ultrasonic fusion method. Transmission electron microscopy was used to observe the morphology of the nanoparticles. The particle size distribution of nanoparticles at day 1 and their potential distribution at days 1，3，5，and 7 were measured using a Malvern particle size analyzer to detect their stability. Western blot and Coomassie brilliant blue staining were used to detect the encapsulation of nanoparticles with MiCM. The functional state of the mouse brain was detected using brain staining with 2，3，5-triphenyltetrazolium chloride and animal behavior test. Results MiCM@PFH@Lipid nanoparticles were spherical in shape，with a particle size of （234.800±3.143） nm and an average potential of （-33.433±1.550） mV. The nanoparticles were well dispersed and stable within 7 days. MiCM was successfully encapsulated on the nanoparticles. Mouse ex vivo fluorescence image showed that the nanoparticles could rapidly accumulate at the site of injury，which was significantly different as compared with the non-targeted group（P<0.05）. Animal behavior test and brain staining showed that MiCM@PFH@Lipid nanoparticles could achieve vascular recanalization and partly restore neurological functions（P<0.05）. Pathological examination showed that there was no significant damage to important organs after nanoparticle treatment. Routine blood test showed no significant abnormality as compared with the normal control group（P<0.05）. Conclusion In this study，multifunctional nanoparticles（MiCM@PFH@Lipid） were successfully prepared. These nanoparticles can target the injured brain area after ischemic stroke and destroy thrombus，and thus can be used for the treatment of ischemic stroke.