Research advances in the regulating mechanism of oxidative stress in rheumatoid arthritis and intervention with traditional Chinese medicine

Luo Meixiu, Pan Zhi, Wang Yinghang

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Journal of Chongqing Medical University ›› 2024, Vol. 49 ›› Issue (10) : 1055-1060. DOI: 10.13406/j.cnki.cyxb.003509
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Research advances in the regulating mechanism of oxidative stress in rheumatoid arthritis and intervention with traditional Chinese medicine

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Abstract

Rheumatoid arthritis（RA） is a chronic，systemic autoimmune disease，with erosive arthritis as its main manifestation. The pathogenesis of the disease is unclear，but recent studies have found that the development of RA is related to oxidative stress. Therefore，oxidative stress may be one of its pathogenic mechanisms. Studies have shown that traditional Chinese medicine（TCM），as an antioxidative means of preventing and treating RA，has the following advantages：multi-level and multi-target action，a favorable safety profile，and fewer side effects. This article reviews the current status of prevention and treatment of RA with TCM based on the oxidative stress mechanism and summarizes and analyzes the factors and pathways related to its main mechanisms of action. It aims to provide a theoretical basis for clinical research and shed light on the directions for basic research.

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oxidative stress / rheumatoid arthritis / traditional Chinese medicine

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Luo Meixiu , Pan Zhi , Wang Yinghang. Research advances in the regulating mechanism of oxidative stress in rheumatoid arthritis and intervention with traditional Chinese medicine. Journal of Chongqing Medical University. 2024, 49(10): 1055-1060 https://doi.org/10.13406/j.cnki.cyxb.003509

References

List( Publishing order | Descend order by publishing year | Descend order by cited within ) Chart analysis
1
姜　泉. 国际中医临床实践指南 类风湿关节炎[J]. 世界中医药，2020，15（20）：3160-3168．
Jiang Q. International clinical practice guideline of Chinese medicine rheumatoid arthritis [J]. World Chin Med，2020，15（20）：3160-3168．
本文引用 [2]
2
Zamudio-Cuevas Y， Martínez-Flores K， Martínez-Nava GA，et al. Rheumatoid arthritis and oxidative stress[J]. Cell Mol Biol，2022，68（6）：174-184.
本文引用 [1]
3
Kerschbaumer A， Sepriano A， Smolen JS，et al. Efficacy of pharmacological treatment in rheumatoid arthritis：a systematic literature research informing the 2019 update of the EULAR recommendations for management of rheumatoid arthritis[J]. Ann Rheum Dis，2020，79（6）：744-759．
本文引用 [1]
4
马丽文，于　丹，吴军凯，等. 中药及有效成分治疗类风湿关节炎的作用机制[J]. 河北医药，2020，42（18）：2832-2836，2841.
Ma LW， Yu D， Wu JK，et al. The action mechanism of traditional Chinese medicine and its activeingredients in treatment of rheumatoid arthritis[J]. Hebei Medical Journal，2020，42（18）：2832-2836，2841.
本文引用 [1]
5
Phull AR， Nasir B， Haq IU，et al. Oxidative stress，consequences and ROS mediated cellular signaling in rheumatoid arthritis[J]. Chem Biol Interact，2018，281：121-136．
本文引用 [1]
6
Sharifi-Rad M， Anil Kumar NV， Zucca P，et al. Lifestyle，oxidative stress，and antioxidants：back and forth in the pathophysiology of chronic diseases[J]. Front Physiol，2020，11：694．
本文引用 [1]
7
Mateen S， Moin S， Khan AQ，et al. Increased reactive oxygen species formation and oxidative stress in rheumatoid arthritis[J]. PLoS One，2016，11（4）：e0152925．
本文引用 [1]
8
赵幸熬，娄玉钤，张广辉，等. 健膝丸对大鼠膝骨关节炎SOD、MDA、NO的影响[J]. 风湿病与关节炎，2013，2（9）：37-40，49．
Zhao XA， Lou YQ， Zhang GH，et al. Influence of Jianxi pill on superoxide dismutase，malondialdehyde and nitric oxide of rats with knee osteoarthritis[J]. Rheum Arthritis，2013，2（9）：37-40，49．
本文引用 [1]
9
秦　梦，王和鸣，娄玉钤. 骨痹舒片对实验性膝骨关节炎病理形态及自由基的影响[J]. 中国中医骨伤科杂志，2011，19（3）：1-3．
Qin M， Wang HM， Lou YQ. Effect of gubishu tablet on pathomorphology and free radical of experimental knee osteoarthritis[J]. Chin J Tradit Med Traumatol Orthop，2011，19（3）：1-3．
本文引用 [1]
10
Yamamoto M， Kensler TW， Motohashi H. The KEAP1-NRF2 system：a thiol-based sensor-effector apparatus for maintaining redox homeostasis[J]. Physiol Rev，2018，98（3）：1169-1203．
本文引用 [2]
11
Holmström KM， Kostov RV， Dinkova-Kostova AT. The multifaceted role of Nrf2 in mitochondrial function[J]. Curr Opin Toxicol，2016，1：80-91．
本文引用 [2]
12
Yang M， Huang Y， Chen J，et al. Activation of AMPK participates hydrogen sulfide-induced cyto-protective effect against dexamethasone in osteoblastic MC3T3-E1 cells[J]. Biochem Biophys Res Commun，2014，454（1）：42-47．
本文引用 [2]
13
Kim J， Choi H， Cho EG，et al. FoxO3a is an antimelanogenic factor that mediates antioxidant-induced depigmentation[J]. J Invest Dermatol，2014，134（5）：1378-1388．
本文引用 [1]
14
Li L， Hong HH， Chen SP，et al. Activation of AMPK/MnSOD signaling mediates anti-apoptotic effect of hepatitis B virus in hepatoma cells[J]. World J Gastroenterol，2016，22（17）：4345-4353．
本文引用 [1]
15
Bernardo A， Giammarco ML， De Nuccio C，et al. Docosahexaenoic acid promotes oligodendrocyte differentiation via PPAR-γ signalling and prevents tumor necrosis factor-α-dependent maturational arrest[J]. Biochim Biophys Acta Mol Cell Biol Lipids，2017，1862（9）：1013-1023．
本文引用 [2]
16
Liu S， Ma HX， Zhang HX，et al. Recent advances on signaling pathways and their inhibitors in rheumatoid arthritis[J]. Clin Immunol，2021，230：108793．
本文引用 [2]
17
Hu SN， Wu YL， Zhao B，et al. Panax notoginseng saponins protect cerebral microvascular endothelial cells against oxygen-glucose deprivation/reperfusion-induced barrier dysfunction via activation of PI3K/akt/Nrf2 antioxidant signaling pathway[J]. Molecules，2018，23（11）：2781．
本文引用 [2]
18
曹春浩，曾　丽，荣晓凤. 大黄素治疗类风湿关节炎的作用机制：基于网络药理学方法[J]. 南方医科大学学报，2022，42（6）：913-921．
Cao CH， Zeng L， Rong XF. Therapeutic mechanism of emodin for treatment of rheumatoid arthritis：a network pharmacology-based analysis[J]. J South Med Univ，2022，42（6）：913-921．
本文引用 [2]
19
成鼎文，朱海丽，谢　敏，等. 大黄素缓解类风湿关节炎痛的机制研究[J]. 中国医药科学，2023，13（1）：20-23，40．
Cheng DW， Zhu HL， Xie M，et al. Investigation on the mechanism of emodin in relieving rheumatoidarthritis pain[J]. China Med Pharm，2023，13（1）：20-23，40．
本文引用 [2]
20
Mohammadian Haftcheshmeh S， Momtazi-Borojeni AA. Immunomodulatory therapeutic effects of curcumin in rheumatoid arthritis[J]. Autoimmun Rev，2020，19（8）：102593．
本文引用 [2]
21
Bisset S， Sobhi W， Attoui A，et al. Targeting oxidative stress markers，xanthine oxidase，TNFRSF11A and cathepsin L in curcumin-treated collagen-induced arthritis：a physiological and COSMO-RS study[J]. Inflammation，2023，46（1）：432-452．
本文引用 [2]
22
Xiao C， Li J， Dong XX，et al. Anti-oxidative and TNF-α suppressive activities of puerarin derivative（4AC） in RAW264.7 cells and collagen-induced arthritic rats[J]. Eur J Pharmacol，2011，666（1/2/3）：242-250．
本文引用 [2]
23
Ganesan R， Rasool M. Ferulic acid inhibits interleukin 17-dependent expression of nodal pathogenic mediators in fibroblast-like synoviocytes of rheumatoid arthritis[J]. J Cell Biochem，2019，120（2）：1878-1893．
本文引用 [2]
24
Zhang JL， Guan YM， He LF，et al. Influence of a combination of triptolide and ferulic acid on the activities of CYP450 enzymes and oxidative stress in HaCaT cells[J]. Exp Ther Med，2020，20（6）：157．
本文引用 [2]
25
杨　欣，王　乐. 桔梗提取物对类风湿性关节炎大鼠的抗炎作用[J]. 现代食品科技，2020，36（1）：22-27．
Yang X， Wang L. Anti-inflammatory effects of an extract from Platycodon grandiflorum on rats with rheumatoid arthritis[J]. Mod Food Sci Technol，2020，36（1）：22-27．
本文引用 [2]
26
Mateen S， Rehman MT， Shahzad S，et al. Anti-oxidant and anti-inflammatory effects of cinnamaldehyde and eugenol on mononuclear cells of rheumatoid arthritis patients[J]. Eur J Pharmacol，2019，852：14-24．
本文引用 [2]
27
金　鑫，朱　江，张煜伟，等. 京尼平苷酸对佐剂性关节炎模型大鼠滑膜细胞体外培养增殖及分泌细胞因子的影响[J]. 中国药房，2010，21（37）：3472-3474．
Jin X， Zhu J， Zhang YW，et al. Effect of geniposide acid on the proliferation and cytokines secretion of synoviocytes in rats with adjuvant-induced arthritis in vitro [J]. China Pharm，2010，21（37）：3472-3474．
本文引用 [2]
28
邢蕴蕴. 杜仲皮、叶、雄花对CIA关节炎模型大鼠的骨保护作用研究[D]. 上海：上海中医药大学，2020．
Xing WW/. Effects of Eucommia ulmoides bark，leaves and male flowers on collagen Ⅱ-induced arthritis in rats[D]. Shanghai：Shanghai University of Traditional Chinese Medicine，2020．
本文引用 [2]
29
Shen Y， Fan XT， Qu YH，et al. Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro [J]. Phytomedicine，2022，104：154339．
本文引用 [2]
30
Wang F， Zhao SC， Li F，et al. Investigation of antioxidant interactions between Radix Astragali and Cimicifuga foetida and identification of synergistic antioxidant compounds[J]. PLoS One，2014，9（1）：e87221.
本文引用 [2]
31
Xu TF， Feng GF， Zhao B，et al. A non-target urinary and serum metabolomics strategy reveals therapeutical mechanism of Radix Astragali on adjuvant-induced arthritis rats[J]. J Chromatogr B Analyt Technol Biomed Life Sci，2017，1048：94-101．
本文引用 [2]
32
Mao X， Li WJ， Chen WJ，et al. Exploring and characterizing a novel combination of paeoniflorin and talatizidine for the treatment of rheumatoid arthritis[J]. Pharmacol Res，2020，153：104658．
本文引用 [2]
33
张博纶，鞠宝兆，张　咪，等. 基于网络药理学-分子对接探讨益气养阴通络方抗类风湿关节炎的作用机制[J]. 天津中医药，2023，40（8）：1065-1074．
Zhang BL， Ju BZ， Zhang M，et al. Discussion on the mechanism of Yiqi Yangyin Tongluo Recipe in anti-rheumatoid arthritis based on network pharmacology-molecular docking[J]. Tianjin J Tradit Chin Med，2023，40（8）：1065-1074．
本文引用 [2]
34
Chetia P， Khandelwal B， Haldar PK，et al. Dietary antioxidants significantly reduced phorbol myristate acetate induced oxidative stress of peripheral blood mononuclear cells of patients with rheumatoid arthritis[J]. Curr Rheumatol Rev，2021，17（1）：81-87．
本文引用 [2]
35
石楸鸣. 独活寄生汤的药理作用及临床应用[J]. 中国医院用药评价与分析，2010，10（6）：575-576．
Shi QM. Pharmacological action and clinical application of Duhuo Jisheng Decoction[J]. Eval Anal Drug Use Hosp China，2010，10（6）：575-576．
本文引用 [2]
36
高晓鹏，鲁贵生. 独活寄生汤改善佐剂性关节炎大鼠氧化应激机制探讨[J]. 广州中医药大学学报，2018，35（4）：683-689．
Gao XP， Lu GS. Mechanism of Duhuo Jisheng Decoction in improving oxidative stress in adjuvant-induced arthritis rats[J]. J Guangzhou Univ Tradit Chin Med，2018，35（4）：683-689．
本文引用 [2]
37
赵雨薇，高玉亭，李　振，等. 二妙散治疗类风湿关节炎的作用机制[J]. 中国组织工程研究，2022，26（5）：742-748．
Zhao YW， Gao YT， Li Z，et al. Mechanism of Ermiao San in the treatment of rheumatoid arthritis[J]. Chin J Tissue Eng Res，2022，26（5）：742-748．
本文引用 [2]
38
Huang YT， Guo LB， Chitti R，et al. Wogonin ameliorate complete Freund’s adjuvant induced rheumatoid arthritis via targeting NF-κB/MAPK signaling pathway[J]. BioFactors，2020，46（2）：283-291．
本文引用 [2]
39
郭锦晨，刘　健，王　键，等. 基于AMPK-FoxO3a-MnSOD信号通路探讨类风湿关节炎患者氧化应激的机制及黄芩清热除痹胶囊对其影响[J]. 免疫学杂志，2019，35（8）：681-690．
Guo JC， Liu J， Wang J，et al. Effects of Huangqin Qingre Chubi capsule on oxidative stress in rheumatoid arthritis patients and its mechanism based on AMPK-FoxO3a-MnSOD signaling pathway[J]. Immunol J，2019，35（8）：681-690．
本文引用 [2]
40
Wang H， Huang Y， Shen P，et al. Modified Si-Miao pill for rheumatoid arthritis：a systematic review and meta-analysis[J]. Evid Based Complement Alternat Med，2020，2020：7672152．
本文引用 [2]
41
沈　盼，巴　鑫，黄　谣，等. 四妙丸调控Nrf2/HO-1/PTEN通路介导的抗炎和抗氧化应激治疗胶原诱导性关节炎的机制研究[C]//中国中西医结合学会基础理论专业委员会年会论文集. 广州：中西医结合学会，2019：49-50.
Shen P， Ba X， Huang Y，et al. Study on the mechanism of Simiao Pill regulating Nrf2/HO-1/PTEN pathway-mediated anti-inflammatory and anti-oxidative stress in the treatment of collagen-induced arthritis[C]// Proceedings of the Annual Meeting of the Basic Theory Committee of the Chinese Society of Integrated Traditional Chinese and Western Medicine. Guangzhou：Society of Integrated Traditional Chinese and Western Medicine，2019：49-50.
本文引用 [2]

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