Objective To translate and revise Alzheimer's disease-related quality of life（ADRQL） scale，and to evaluate its reliability and validity. Methods The Brislin's translation model for cross-cultural research was used to translate the English version of ADRQL scale，and the translated scale was culturally adapted through expert panel discussion and pre-survey. The convenience sampling method was used to investigate 221 caregivers of the patients with Alzheimer's disease or other types of dementia who attended Ruijin Hospital and community health service centers from December 2022 to June 2023. The Cronbach's alpha coefficient was used to measure the correlation of the results and evaluate the reliability of the scale； the expert evaluation method was used to evaluate the content validity of the scale；the exploratory factor analysis was used to evaluate the structural validity of the scale. Results The Bartlett's spherical test of the Chinese version of the ADRQL scale was χ²=2 466.634，P<0.001，with a KMO value of 0.727. Eight common factors were extracted by the exploratory factor analysis，with a cumulative variance contribution rate of 47.37%. The content validity index was 0.99 at the scale level and was 0.83-1.00 at the entry level. The Cronbach's alpha coefficient was 0.809 for the total scale，with a split-half reliability coefficient of 0.860. Conclusion The Chinese version of the ADRQL scale has good reliability and validity and can be used to assess quality of life in patients with Alzheimer's disease or other types of dementia in China.