Advances in invasive neuromodulation therapy for gait disturbance in Parkinson's disease

Zeng Zhitong, Huang Peng, Sun Bomin, Li Dianyou

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Journal of Chongqing Medical University ›› 2024, Vol. 49 ›› Issue (05) : 548-551. DOI: 10.13406/j.cnki.cyxb.003486
Treatment of movement disorders

Advances in invasive neuromodulation therapy for gait disturbance in Parkinson's disease

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Abstract

Gait disturbance is one of the most common axial symptoms in Parkinson's disease(PD),and it severely impairs the mobility and quality of life of patients. Neuromodulation is an important therapy in addition to pharmacotherapy,exercise,and rehabilitation,among which invasive surgery is a commonly used modulation method. Due to the high prevalence rate of gait disturbance in PD and the limitations of existing therapies,studies for new targets and techniques have been conducted for invasive neuromodulation in recent years. This article reviews the advances and prospects of invasive neuromodulation in the treatment of gait disturbance in PD.

Key words

Parkinson's disease / gait disturbance / invasive neuromodulation / deep brain stimulation

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Zeng Zhitong , Huang Peng , Sun Bomin , et al. Advances in invasive neuromodulation therapy for gait disturbance in Parkinson's disease. Journal of Chongqing Medical University. 2024, 49(05): 548-551 https://doi.org/10.13406/j.cnki.cyxb.003486

References

1
Mirelman A Bonato P Camicioli R,et al. Gait impairments in Parkinson's disease[J]. Lancet Neurol201918(7):697-708.
2
Giladi N Horak FB Hausdorff JM. Classification of gait disturbances:distinguishing between continuous and episodic changes[J]. Mov Disord201328(11):1469-1473.
3
中华医学会神经病学分会帕金森病及运动障碍学组,中国医师协会神经内科医师分会帕金森病及运动障碍学组. 中国帕金森病治疗指南(第四版)[J]. 中华神经科杂志202053(12):973-986.
Chinese Society of Parkinson's Disease and Movement Disorders,Parkinson's disease and movement disorder section of neurologist branch of Chinese medical doctor association. Chinese guidelines for the treatment of Parkinson's disease(fourth edition)[J]. Chinese Journal of Neurology202053(12):973-986.
4
曹学兵,唐北沙,刘振国. 帕金森病冻结步态中西医诊治专家共识(2021)[J]. 卒中与神经疾病202128(5):599-604.
Cao XB Tang BS Liu ZG. Consensus of experts in diagnosis and treatment of Parkinson's disease with frozen gait(2021)[J]. Stroke Nerv Dis202128(5):599-604.
5
Tykocki T Mandat T Nauman P. Pedunculopontine nucleus deep brain stimulation in Parkinson's disease[J]. Arch Med Sci20117(4):555-564.
6
Bourilhon J Olivier C You HN,et al. Pedunculopontine and cuneiform nuclei deep brain stimulation for severe gait and balance disorders in Parkinson's disease:interim results from a randomized double-blind clinical trial[J]. J Parkinsons Dis202212(2):639-653.
7
Bourilhon J Mullie Y Olivier C,et al. Stimulation of the pedunculopontine and cuneiform nuclei for freezing of gait and falls in Parkinson disease:cross-over single-blinded study and long-term follow-up[J]. Parkinsonism Relat Disord202296:13-17.
8
Weiss D Walach M Meisner C,et al. Nigral stimulation for resistant axial motor impairment in Parkinson's disease?A randomized controlled trial[J]. Brain2013136(Pt 7):2098-2108.
9
Valldeoriola F. Simultaneous low-frequency deep brain stimulation of the substantia nigra pars reticulata and high-frequency stimulation of the subthalamic nucleus to treat levodopa unresponsive freezing of gait in Parkinson's disease:a pilot study[J]. Parkinsonism Relat Disord201963:231.
10
Scholten M Klemt J Heilbronn M,et al. Effects of subthalamic and nigral stimulation on gait kinematics in Parkinson's disease[J]. Front Neurol20178:543.
11
Heilbronn M Scholten M Schlenstedt C,et al. Anticipatory postural adjustments are modulated by substantia nigra stimulation in people with Parkinson's disease and freezing of gait[J]. Parkinsonism Relat Disord201966:34-39.
12
Cury RG Pavese N Aziz TZ,et al. Gaps and roadmap of novel neuromodulation targets for treatment of gait in Parkinson's disease[J]. NPJ Parkinsons Dis20228(1):8.
13
Lizarraga KJ Luca CC De Salles A,et al. Asymmetric neuromodulation of motor circuits in Parkinson's disease:the role of subthalamic deep brain stimulation[J]. Surg Neurol Int20178:261.
14
Meoni S Debû B Pelissier P,et al. Asymmetric STN DBS for FOG in Parkinson's disease:a pilot trial[J]. Parkinsonism Relat Disord201963:94-99.
15
Lizárraga KJ Gnanamanogaran B Al-Ozzi TM,et al. Lateralized subthalamic stimulation for axial dysfunction in Parkinson's disease:a randomized trial[J]. Mov Disord202237(5):1079-1087.
16
Xie T Padmanaban M Bloom L,et al. Effect of low versus high frequency stimulation on freezing of gait and other axial symptoms in Parkinson patients with bilateral STN DBS:a mini-review[J]. Transl Neurodegener20176:13.
17
Moreau C Defebvre L Destee A,et al. STN-DBS frequency effects on freezing of gait in advanced Parkinson disease[J]. Neurology200871(2):80-84.
18
Vijiaratnam N Girges C Wirth T,et al. Long-term success of low-frequency subthalamic nucleus stimulation for Parkinson's disease depends on tremor severity and symptom duration[J]. Brain Commun20213(3):fcab165.
19
Annic A Moreau C Salleron J,et al. Predictive factors for improvement of gait by low-frequency stimulation in Parkinson's disease[J]. J Parkinsons Dis20144(3):413-420.
20
Su DN Chen HM Hu WL,et al. Frequency-dependent effects of subthalamic deep brain stimulation on motor symptoms in Parkinson's disease:a meta-analysis of controlled trials[J]. Sci Rep20188(1):14456.
21
Jia FM Guo Y Wan S,et al. Variable frequency stimulation of subthalamic nucleus for freezing of gait in Parkinson's disease[J]. Parkinsonism Relat Disord201521(12):1471-1472.
22
Jia FM Hu W Zhang JG,et al. Variable frequency stimulation of subthalamic nucleus in Parkinson's disease:rationale and hypothesis[J]. Parkinsonism Relat Disord201739:27-30.
23
Jia FM Wagle Shukla A Hu W,et al. Deep brain stimulation at variable frequency to improve motor outcomes in Parkinson's disease[J]. Mov Disord Clin Pract20185(5):538-541.
24
Jia FM Zhang JG Wang HM,et al. Variable- versus constant-frequency deep-brain stimulation in patients with advanced Parkinson's disease:study protocol for a randomized controlled trial[J]. Trials201920(1):749.
25
Petrucci MN Neuville RS Afzal MF,et al. Neural closed-loop deep brain stimulation for freezing of gait[J]. Brain Stimul202013(5):1320-1322.
26
Molina R Hass CJ Cernera S,et al. Closed-loop deep brain stimulation to treat medication-refractory freezing of gait in Parkinson's disease[J]. Front Hum Neurosci202115:633655.
27
Streumer J Selvaraj AK Kurt E,et al. Does spinal cord stimulation improve gait in Parkinson's disease:a comprehensive review[J]. Parkinsonism Relat Disord2023109:105331.
28
Samotus O Parrent A Jog M. Spinal cord stimulation therapy for gait dysfunction in advanced Parkinson's disease patients[J]. Mov Disord201833(5):783-792.
29
Prasad S Aguirre-Padilla DH Poon YY,et al. Spinal cord stimulation for very advanced Parkinson's disease:a 1-year prospective trial[J]. Mov Disord202035(6):1082-1083.
30
Zhang CC Wang LB Pan YX,et al. Sacral nerve stimulation improves gait in Parkinson's disease[J]. Brain Stimul201912(4):1075-1076.
31
Gilat M Ginis P Zoetewei D,et al. A systematic review on exercise and training-based interventions for freezing of gait in Parkinson's disease[J]. NPJ Parkinsons Dis20217(1):81.
32
Nonnekes J Snijders AH Nutt JG,et al. Freezing of gait:a practical approach to management[J]. Lancet Neurol201514(7):768-778.
33
Milekovic T Moraud EM Macellari N,et al. A spinal cord neuroprosthesis for locomotor deficits due to Parkinson's disease[J]. Nat Med202329(11):2854-2865.

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