Progress in the application of in vivo confocal microscopy in different types of dry eye examination

Wang Xi, Zhang Qi

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Journal of Chongqing Medical University ›› 2024, Vol. 49 ›› Issue (02) : 114-117. DOI: 10.13406/j.cnki.cyxb.003430
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Progress in the application of in vivo confocal microscopy in different types of dry eye examination

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Abstract

The pathogenesis of dry eye is complex，and various etiology will eventually lead to corneal and conjunctival injury and cause a series of eye discomfort symptoms. Understanding the pathological changes of the ocular surface in patients with dry eye is of great significance for the diagnosis and treatment of the disease. In recent years，in vivo confocal microscopy（IVCM） has been increasingly used to study the microscopic world of dry eyes. IVCM is a non-invasive imaging tool that can examine the changes in corneal cells and nerve fibers noninvasively in real time，evaluate various structures such as meibomian glands，and provide better help in understanding the pathogenesis of dry eye and histological changes at the cellular level. This paper summarizes the changes of ocular surface of different types of dry eye under IVCM in order to further understand the pathological changes of each type of dry eye and assist clinical diagnosis and treatment.

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dry eye / in vivo confocal microscopy / ocular surface / histocyte

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Wang Xi , Zhang Qi. Progress in the application of in vivo confocal microscopy in different types of dry eye examination. Journal of Chongqing Medical University. 2024, 49(02): 114-117 https://doi.org/10.13406/j.cnki.cyxb.003430

References

List( Publishing order | Descend order by publishing year | Descend order by cited within ) Chart analysis
1
Stapleton F， Alves M， Bunya VY，et al. TFOS DEWS Ⅱ epidemiology report[J]. Ocul Surf，2017，15（3）：334-365．
本文引用 [1]
2
Sim R， Yong K， Liu YC，et al. In vivo confocal microscopy in different types of dry eye and meibomian gland dysfunction[J]. J Clin Med，2022，11（9）：2349．
本文引用 [1]
3
Vehof J， Utheim TP， Bootsma H，et al. Advances，limitations and future perspectives in the diagnosis and management of dry eye in Sjögren's syndrome[J]. Clin Exp Rheumatol，2020，38（4）：301-309．
本文引用 [1]
4
Labbé A， Liang QF， Wang ZQ，et al. Corneal nerve structure and function in patients with non-sjogren dry eye：clinical correlations[J]. Invest Ophthalmol Vis Sci，2013，54（8）：5144-5150．
本文引用 [1]
5
Lanza M， Iaccarino S， Varricchi G，et al. Corneal confocal microscopy alterations in Sjögren's syndrome dry eye[J]. Acta Ophthalmol，2017，95（5）：e366-e372．
本文引用 [1]
6
Cardigos J， Barcelos F， Carvalho H，et al. Tear Meniscus and corneal sub-basal nerve plexus assessment in primary sjögren syndrome and sicca syndrome patients[J]. Cornea，2019，38（2）：221-228．
本文引用 [1]
7
Alhatem A， Cavalcanti B， Hamrah P. In vivo confocal microscopy in dry eye disease and related conditions[J]. Semin Ophthalmol，2012，27（5/6）：138-148．
本文引用 [1]
8
Kheirkhah A， Rahimi Darabad R， Cruzat A，et al. Corneal epithelial immune dendritic cell alterations in subtypes of dry eye disease：a pilot in vivo confocal microscopic study[J]. Invest Ophthalmol Vis Sci，2015，56（12）：7179-7185．
本文引用 [1]
9
Machetta F， Fea AM， Actis AG，et al. In vivo confocal microscopic evaluation of corneal Langerhans cells in dry eye patients[J]. Open Ophthalmol J，2014，8：51-59．
本文引用 [1]
10
Matsumoto Y， Ibrahim OMA. Application of in vivo confocal microscopy in dry eye disease[J]. Invest Ophthalmol Vis Sci，2018，59（14）：41-47．
本文引用 [1]
11
Kheirkhah A， Saboo US， Abud TB，et al. Reduced corneal endothelial cell density in patients with dry eye disease[J]. Am J Ophthalmol，2015，159（6）：1022-1026．
本文引用 [1]
12
Fea AM， Aragno V， Testa V，et al. The effect of autologous platelet lysate eye drops：an in vivo confocal microscopy study[J]. Biomed Res Int，2016，2016：830-842．
本文引用 [1]
13
Gabbriellini G， Baldini C， Varanini V，et al. In vivo confocal scanning laser microscopy in patients with primary Sjögren's syndrome：a monocentric experience[J]. Mod Rheumatol，2015，25（4）：585-589．
14
Iaccheri B， Torroni G， Cagini C，et al. Corneal confocal scanning laser microscopy in patients with dry eye disease treated with topical cyclosporine[J]. Eye，2017，31（5）：788-794．
15
Tepelus TC， Chiu GB， Huang JY，et al. Correlation between corneal innervation and inflammation evaluated with confocal microscopy and symptomatology in patients with dry eye syndromes：a preliminary study[J]. Albrecht Von Graefes Arch Fur Klin Und Exp Ophthalmol，2017，255（9）：1771-1778．
16
Villani E， Galimberti D， del Papa N，et al. Inflammation in dry eye associated with rheumatoid arthritis：cytokine and in vivo confocal microscopy study[J]. Innate Immun，2013，19（4）：420-427．
17
Villani E， Magnani F， Viola F，et al. In vivo confocal evaluation of the ocular surface morpho-functional unit in dry eye[J]. Optom Vis Sci，2013，90（6）：576-586．
本文引用 [2]
18
Cruzat A， Pavan-Langston D， Hamrah P. In vivo confocal microscopy of corneal nerves：analysis and clinical correlation[J]. Semin Ophthalmol，2010，25（5/6）：171-177．
本文引用 [1]
19
Yang T， Delli K， Coumou AD，et al. The lacrimal gland in Sjögren's syndrome：can we unravel its mystery using ultrasound?[J]. Clin Exp Rheumatol，2022，40（12）：2428-2433．
本文引用 [1]
20
Mokhtarzadeh M， Casey R， Glasgow BJ. Fluorescein punctate staining traced to superficial corneal epithelial cells by impression cytology and confocal microscopy[J]. Invest Ophthalmol Vis Sci，2011，52（5）：2127-2135．
本文引用 [1]
21
刘　瑞，李　冰，盛敏杰. 活体共聚焦显微镜在干燥综合征眼表形态观察中的应用[J]. 国际眼科杂志，2016，16（12）：2213-2216．
Liu R， Li B， Sheng MJ. Application of in vivo confocal microscopy for ocular surface observing in patients with Sj gren's syndrome[J]. Int Eye Sci，2016，16（12）：2213-2216．
本文引用 [1]
22
Kojima T， Matsumoto Y， Dogru M，et al. The application of in vivo laser scanning confocal microscopy as a tool of conjunctival in vivo cytology in the diagnosis of dry eye ocular surface disease[J]. Mol Vis，2010，16：2457-2464．
本文引用 [1]
23
Lam SM， Tong L， Duan XR，et al. Longitudinal changes in tear fluid lipidome brought about by eyelid-warming treatment in a cohort of meibomian gland dysfunction[J]. J Lipid Res，2014，55（9）：1959-1969．
本文引用 [1]
24
Fu JY， Chou YL， Hao R，et al. Evaluation of ocular surface impairment in meibomian gland dysfunction of varying severity using a comprehensive grading scale[J]. Medicine，2019，98（31）：e16547．
本文引用 [1]
25
Villani E， Canton V， Magnani F，et al. The aging Meibomian gland：an in vivo confocal study[J]. Invest Ophthalmol Vis Sci，2013，54（7）：4735-4740．
本文引用 [1]
26
Qazi Y， Kheirkhah A， Blackie C，et al. In vivo detection of clinically non-apparent ocular surface inflammation in patients with meibomian gland dysfunction-associated refractory dry eye symptoms：a pilot study[J]. Eye，2015，29（8）：1099-1110．
本文引用 [1]
27
Liang QF， Gao C， Liang H，et al. In vivo confocal microscopy evaluation of meibomian glands in meibomian gland dysfunction patients[J].Journal of the Formosan Medical Association，2016，52（9）：649-656.
本文引用 [1]
28
Villani E， Ceresara G， Beretta S，et al. In vivo confocal microscopy of meibomian glands in contact lens wearers[J]. Invest Ophthalmol Vis Sci，2011，52（8）：5215-5219．
本文引用 [1]
29
Mastropasqua R， Agnifili L， Fasanella V，et al. In vivo distribution of corneal epithelial dendritic cells in patients with glaucoma[J]. Invest Ophthalmol Vis Sci，2016，57（14）：5996-6002．
本文引用 [1]
30
Georgiev GA， Eftimov P， Yokoi N. Contribution of mucins towards the physical properties of the tear film：a modern update[J]. Int J Mol Sci，2019，20（24）：6132．
本文引用 [1]
31
Staso SD， Agnifili L， Ciancaglini M，et al. In vivo scanning laser confocal microscopy of conjunctival goblet cells in medically-controlled glaucoma[J]. In Vivo，2018，32（2）：437-443．
本文引用 [1]
32
Agnifili L， Fasanella V， Mastropasqua R，et al. In vivo goblet cell density as a potential indicator of glaucoma filtration surgery outcome[J]. Invest Ophthalmol Vis Sci，2016，57（7）：2928-2935．
本文引用 [1]
33
Kam KW， Di Zazzo A， De Gregorio C，et al. A review on drug-induced dry eye disease[J]. Indian J Ophthalmol，2023，71（4）：1263-1269．
本文引用 [1]
34
Mastropasqua L， Agnifili L， Mastropasqua R，et al. In vivo laser scanning confocal microscopy of the ocular surface in glaucoma[J]. Microsc Microanal，2014，20（3）：879-894．
本文引用 [1]
35
Wei YH， Chen WL， Hu FR，et al. In vivo confocal microscopy of bulbar conjunctiva in patients with Graves' ophthalmopathy[J]，2015，114（10）：965-972．
本文引用 [1]
36
Wu LQ， Cheng JW， Cai JP，et al. Observation of corneal Langerhans cells by in vivo confocal microscopy in thyroid-associated ophthalmopathy[J]. Curr Eye Res，2016，41（7）：927-932．
37
Kocabeyoglu S， Mocan MC， Cevik Y，et al. Ocular surface alterations and in vivo confocal microscopic features of corneas in patients with newly diagnosed Graves' disease[J]. Cornea，2015，34（7）：745-749．
本文引用 [1]
38
Cheng SN， Yu YQ， Chen J，et al. In vivo confocal microscopy assessment of meibomian glands microstructure in patients with Graves' orbitopathy[J]. BMC Ophthalmol，2021，21（1）：261．
本文引用 [1]
39
程胜男，姜发纲，游雅琰，等. 活体共聚焦显微镜对甲状腺相关眼病患者睑板腺微观结构的观察研究[J]. 华中科技大学学报（医学版），2022，51（5）：676-682．
Cheng SN， Jiang FG， You YY，et al. Observation on the microstructure of meibomian gland in patients with thyroid-associated ophthalmopathy by in vivo confocal microscopy[J]. Acta Med Univ Sci Technol Huazhong，2022，51（5）：676-682．
本文引用 [1]

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