Objective To investigate the efficacy of deep brain stimulation（DBS） at different targets in the treatment of Meige syndrome. Methods A retrospective analysis was performed for the clinical data of eight patients with Meige syndrome who underwent DBS therapy at different targets in Department of Neurosurgery，The First Affiliated Hospital of Chongqing Medical University，from March 2019 to April 2022. The eight patients with primary Meige syndrome received DBS at bilateral subthalamic nucleus（STN） or bilateral globus pallidus internus（GPI）. Burke-Fahn-Marsden Dystonia Rating Scale（BFMDRS），Hamilton Anxiety Scale（HAMA），and Hamilton Depression Scale（HAMD） were used to evaluate the muscle tension，limb motor function，and mental condition of the patients before and after surgery，and postoperative complications were also recorded. Results At 12 months after surgery，the mean improvement rate of BFMDRS was （77.17±11.63）% for the eight patients，and the mean improvement rate of motor score was 76.49% in the patients receiving GPI stimulation and 77.85% in those receiving STN stimulation（P>0.05），suggesting that DBS at both targets could effectively improve the symptoms of patients without significant differences. In addition，there were varying degrees of improvement in HAMA and HAMD scores after surgery. Conclusion DBS treatment at different targets can effectively and safely improve the clinical symptoms of Meige syndrome and can thus be used as an alternative regimen in case of no response to local injection of drugs and botulinum toxins.