The crystal internal stress and texture evolution of six-pass hot rolled ZK61 magnesium alloy plate are studied by means of combining macroscopic finite element simulation and microscopic crystal plasticity analysis. According to the rolling experiment and tensile test， the corresponding synchronous hot rolling model is established and simulated， and the simulation results are entered as boundary conditions in the polycrystalline plasticity model based on Voronoi diagram. Then the crystal plasticity finite element method is used to simulate the synchronous hot rolling of the polycrystalline model， and the plastic parameters and texture pole figures of the hot-rolled ZK61 magnesium alloy in each pass are obtained. Compared with the tensile test results and the texture pole figures derived from the electron backscatter diffraction experiment， the crystal plastic deformation and texture evolution mechanism of the hot-rolled ZK61 magnesium alloy under different passes are summarized. The results show that there are a large number of twins and dynamic recrystallization in the ZK61 plate after multi-pass hot rolling， the grain homogenization and refinement effect is obvious. The pole intensity of basal texture is correlated with the whole rolling passes， the peak misorientation angle of the alloy under different passes has a quite diversity （8°， 28°， and 88°）， and the mechanical properties of the alloy are improved. The alloy strength is increased by 7.55%， and the elongation is achieved by 19.5%. The results can provide reference for improving the plastic processing ability of magnesium alloy.