Active Shrinkage Hydrogel Based on Red Emissive Carbon Dots Photosensitizers for Bacterial Infected Wound Healing

HAO Yongliang, LI Jian, WANG Zehua, GE Jiechao

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Chem J Chin Univ ›› 2025, Vol. 46 ›› Issue (6) : 202-209. DOI: 10.7503/cjcu20240409
Article

Active Shrinkage Hydrogel Based on Red Emissive Carbon Dots Photosensitizers for Bacterial Infected Wound Healing

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Abstract

An active shrinkage hydrogel based on red emissive carbon dots(CDs) photosensitizers(PSs) was developed for bacterial infected wound healing. The hydrogel was prepared by using N-isopropylacrylamide (NIPAM), sodium alginate(SA) and CDs PSs as precursors through free radical polymerization and calcium ion cross-linking. The hydrogel could release CDs PSs at body temperature(37 ℃) due to the active shrinkage of the hydrogel. Upon light irradiation, the released CDs PSs can generate singlet oxygen to kill bacteria effectively in the wound site leading to rapid wound healing. In vitro and in vivo results suggest that the developed active shrinkage hydrogel has good drug release, photodynamic antibacterial effects and the ability to accelerate wound healing, thus providing a new type of hydrogel for clinical wound management.

Key words

Carbon dots / Photodynamic antibacterial / Hydrogel / Wound healing

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HAO Yongliang , LI Jian , WANG Zehua , et al. Active Shrinkage Hydrogel Based on Red Emissive Carbon Dots Photosensitizers for Bacterial Infected Wound Healing. Chemical Journal of Chinese Universities. 2025, 46(6): 202-209 https://doi.org/10.7503/cjcu20240409

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Funding

the National Natural Science Foundation of China(52272052)
the National Key Research and Development Program of China(2022YFA1207600)

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