Objectives A knowledge associated network for the course of "Pig Farming and Prevention and Control of Pig Diseases" was constructed to provide intelligent support for key links including pig breeding, healthy farming, biosafety, prevention and control of diseases and to train technical and skilled talents with high-quality who can comprehensively apply their learned knowledge to solve problems in the production of pig farming and improve the efficiency of farming. Methods The knowledge map was used to integrate the value shaping, knowledge teaching, and ability training into a comprehensive system of assessment and evaluation that includes "dual mentors, dual levels, four links, and four elements". The digital learning resources for the course of "Pig Farming and Prevention and Control of Pig Diseases" were established on the online platform of Xuetang. Results The blended online and offline teaching mode of first-class core course in animal husbandry and veterinary medicine major was innovated. A personalized training program was developed. The fruitful teaching results were achieved. It provide a good resource platform and innovative examples for sister colleges and enterprises of pig farming. Conclusions The use of knowledge map as a teaching strategy can effectively improve the quality of course teaching and the innovation ability of students.