Objectives The infection and mortality of infectious reproductive disorders in pigs from large-scale pig farms in Jingdong Yi Autonomous County, Yunnan Province was investigated to propose measures of preventing and treating reproductive disorders in pigs. Methods An epidemiological investigation and serological testing of infectious reproductive disorders in pigs including porcine reproductive and respiratory syndrome, porcine circovirus disease (PCV Ⅱ), porcine pseudorabies, chronic swine fever, porcine parvovirus disease, porcine encephalitis B, and porcine erysipelas were conducted on three representative large-scale pig farms in Jingdong Yi Autonomous County including Luogeng Pig Farm in Jingfan Village, Lizhongding Pig Farm in Wenlong Sanchahe, and Yangyong Pig Farm in Qiansuo Yinsheng Animal Husbandry Co., Ltd. Results Through a 2-year (2022—2023) investigation and analysis, it was found that porcine reproductive and respiratory syndrome, circovirus disease, pseudorabies, encephalitis, parvovirus, swine fever, and erysipelas were the main diseases causing reproductive disorders in sows in large-scale pig farms in Jingdong Yi Autonomous County. The positive detection rate of porcine eperythrocytic disease, circovirus disease, and pseudorabies was relatively high, at 100%, 63.73%, and 20.8%, respectively, followed by encephalitis, reproductive and respiratory syndrome, and parvovirus with positive rate of 14.04%, 13.84%, and 9.88%, respectively. The detection rate of swine fever was the lowest, at 5.56%. Conclusions Measures including increasing awareness, enhancing publicity, strict quarantine, elimination and disinfection, disinfecting and eliminating sources, and strengthening management can effectively prevent and control reproductive disorders in pigs.