Objectives The feasibility and economic mode of realizing the industrialized aquaculture of pond perch in coastal low salinity areas of China was studied. Methods The development status of pond perch in the Baijiao area of Doumen town with the salinity of water source in pond ranging from 0‰ to 3‰ and the Pingsha area of Jinwan town with the salinity of water source in pond ranging from 2‰ to 12‰ in Zhuhai City, Guangdong Province was investigated and compared. The facilities and equipment, management, and aquaculture techniques of an aquatic breeding base in the Taiwan Innovation Park in Pingsha area of Jinwan town was optimized to conduct the industrialized and economic aquaculture of pond perch. The experimental data, quality, processing rate of "three removal", and tasting were comprehensively analyzed. The economic indexes recommended for industrialized aquaculture and the pathways to achieve industrialization were further summarized. Results Using market circulation of pond perch seedling with a size of about 2.5-3.0 cm (0.5-0.6 g) as the starting mark, the survival rate of marking seedlings with a size of 130 ±15g and rearing was more than 60% and 97%, respectively. The weight of the catch was 750-1 000 g/tail in January of the following year, with the bait coefficient of the rearing period ranging from 1.33 to 1.35 and the cost of (11±1) ¥ /500 g. Conclusions The cost of industrialized aquaculture in large ponds in coastal low salinity areas can fully reach the median cost of dominant aquaculture areas of pond perch at home and abroad. The quality and processing rate of pond perch are excellent, and it has industrial prospects and an advantage of latecomer in the scale layout of the industrial chain.