Objectives In order to optimize the model of educating animal husbandry and veterinary medicine talents and improve the quality of training applied talents in vocational colleges. Methods The problems in the education mechanism of animal husbandry and veterinary majors in Guangdong vocational colleges were analyzed. The program for educating talents in the Animal Husbandry and Veterinary major was explored by taking the Department of Animal Husbandry and Veterinary at Maoming Vocational College of Agricultural and Forestry Technology in Guangdong Province as an example. Results The education goal of " building morality and cultivating people, emphasizing moral integrity and technical skills " was established by building a platform for integrating industry with education, deepening the cooperation between college and enterprise, and optimizing the mechanisms of evaluating talents. A mode of educating talent with the notion of " integrating industry with education, dual-oriented ability, double certification" form. Conclusions The education model established will provide theoretical reference for improving the quality of educating talents in animal husbandry and veterinary medicine in Guangdong region, promoting the development of animal husbandry and veterinary medicine major, and deepening the cooperation between college and enterprise.